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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Environmental fate & pathways


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Administrative data

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Description of key information

Under environmental conditions the hydrolysis half-life of Chlorhexidine base is more than 1 year.

Key value for chemical safety assessment

Additional information

Hydrolysis of Chlorhexidine digluconate and Chlorhexidine dihydrochloride were tested according to OECD Guideline 311 and EEC-Guideline C.07. Both tests were conducted at 50°C over 5 days at different pH values. No significant hydrolysis was observed at all pH values.

In contrast, products of hydrolysis were found in the study of Ackermann using Chlorhexidine diactetate as test substance. However, no pH value is reported. Therefore, these results are considered to be of lower reliability.