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EC number: 214-787-5 | CAS number: 1194-65-6
Table 1: Body weight gain (g)
*statistical significant P≤0.05; **statistical significant P≤0.01
Table 2: Food consumption (g)
Table 3: Selected clinical chemistry values
*statistical significant, P≤0.05; **statistical significant, P≤0.01; results of Student's test since the mean response is not a monotonic function of dose: + P≤0.05, ++ P≤0.01
Table 4: Selected absolute and relative organ weights
*statistical significant, P≤0.05; **statistical significant, P≤0.01; 1 medians are presented and nonparameteric test was applied because of an outlying observation; results of Student's t-test since the mean response is not a monotonic function of dose: + P≤0.05, ++P≤0.01
Table 5: Selected microscopic observations
* incidences yielding statistical significance (P≤0.1) in a two-sided test against trend with dose level; **Shirley's test P≤0.1
In a GLP compliant repeat dose (oral) study conducted in line with EPA OPP 82-1, the effects of the repeat dose of the test material over 90 days was determined. Hamsters were fed a diet containing 0, 41, 209, 1289 and 4648 mg/kg diet (7500 mg/kg diet for first two weeks) test material.
Under the conditions of the test, the NOEL of the test material in a 90 day repeat dose study in the hamster was determined to be 41 mg/kg diet.
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