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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 January 2004 to 23 February 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
capillary method
Remarks:
Thomas-Hoover Melting Point Apparatus
Key result
Melting / freezing pt.:
>= 144 - <= 145 °C
Remarks on result:
other: Assumed atmospheric pressure

Table 1: Calibration results

 Standard  Determination  Specified melting point range (ºC)  Determined melting point range (ºC)
 Phenacetin  1  134.5-136.0  134.0-136.0
 Phenacetin  2  134.5-136.0  134.0-135.0
 Sulfanilamide  1  165.0-166.0  164.0-166.0
 Sulfanilamide  2  165.0-166.0  164.0-165.5

Table 2: Test material results

 Determination  Melting point range (ºC)
 1  143.0-144.5
 2  143.0-144.0
 Average  143.0-144.25
 Adjusted range  144.0-145.25
 Rounded results  144.0-145.0
Conclusions:
Under the conditions of the test, the melting point of the test material was determined to be 144-145 °C.
Executive summary:

In a GLP compliant melting point study conducted in accordance with standardised guidelines EU Method A.1 and EPA OPPTS 830.7200, the melting point of the test material was determined using a Thomas-Hoover Melting Point Apparatus.

Under the conditions of the test, the melting point of the test material was determined to be 144-145 ºC.

Description of key information

The melting point of the test material was determined to be 144-145 ºC according to a study performed in line with EU Method A.1 and EPA OPPTS 830.7200.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
144 °C

Additional information

The key study (Dunn, 2004) was performed in line with GLP and standardised guidelines with a sufficient level of detail to assess the quality of the study. The study was performed to a good standard and was assigned a reliability score of 1 using the principle for assessing data quality as set out in Klimisch (1997).

The supporting study (Berkel et al., 1987) was not performed in line with GLP and contained insufficient detail to assess the quality of the study. The study was assigned a reliability score of 4 using the principle for assessing data quality as set out in Klimisch (1997).