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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
3 December 1999 to 17 December 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to
Guideline:
other: OECD 105
Deviations:
no
Principles of method if other than guideline:
The study was performed to a method based on the principles of the water solubility testing guideline OECD 105.
GLP compliance:
yes (incl. certificate)
Key result
Medium:
ethyl acetate
Solubility:
59.3 g/L
Temp.:
20 °C
Test substance stable:
not determined
Details on results:
The preliminary estimate of solubility in ethyl acetate was 57.1 g/L

Tables 1 and 2: Definitive results

 Solution  Mean peak area
 Standard 602 mg/L  1.766 x 106
 Standard 604 mg/L  1.769 x  106
 Sample 1A  1.728 x  106
 Sample 1B  1.728 x  106
 Sample 2A  1.734 x  106
 Sample 2B  1.732 x  106
 Sample 3A  1.760 x  106
 Sample 3B  1.760 x  106

 Sample number  Time shaken at ~30 ºC  Time equilibrated at 20 ºC hours  Concentration (g/L)
 1  24  24  58.9
 2  48  24  59.1
 3  72  24  60.0

Mean concentration: 59.3 g/L at 20 ± 0.5 ºC

Range: 58.9 to 60 g/L

Conclusions:
Under the conditions of the test, the organic solvent solubility of the test material was determined to be 59.3 g/L in ethyl acetate.
Executive summary:

In a GLP compliant organic solvent solubility study conducted in accordance with a standardised guideline (OECD 105), the solubility of the test material was determined. Under the conditions of the test, the organic solvent solubility of the test material was determined to be 59.3 g/L in ethyl acetate.

Description of key information

The organic solvent solubility was determined to be 59.3 g/L in ethyl acetate at 20 ºC in a study performed in line with OECD 105.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
59.3 g/L

Additional information

A GLP compliant organic solvent solubility study was performed in accordance with a standardised guideline with a sufficient level of detail to assess the quality of the presented data. The study was performed to a good standard and was assigned a reliability score of 1 using the principle for assessing data quality as set out in Klimisch (1997). This study (O'Connor and Mullee, 2000) was considered to be the key study as it was performed to both GLP and a standardised guideline.

A GLP compliant organic solvent solubility study (Riggs, 1999) was performed in accordance with sound scientific principles with a sufficient level of detail to assess the quality of the presented data. The study was performed to a good standard and was assigned a reliability score of 2 using the principle for assessing data quality as set out in Klimisch (1997) on the basis that the study did not follow a recognised guideline.

A non-GLP compliant organic solvent solubility study (Berkel et al., 1987) was performed in accordance with a standardised guideline with a sufficient level of detail to assess the quality of the presented data. The study was performed to a good standard and was assigned a reliability score of 2 using the principle for assessing data quality as set out in Klimisch (1997) on the basis that the study is non-GLP.