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Physical & Chemical properties

Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
8 September 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes
Dissociating properties:
no

No significant differences were exhibited in spectra obtained over the 200-400 nm wavelength at 20 ± 1 ºC in 40 % v/v ethanol/water solutions of 1 x 10-4 M test material prepared at pHs 2.1, 4.0, 6.1, 8.0, 10.1 and 12.1.

Conclusions:
Under the conditions of the study, the test material was observed not to dissociate in a dissociation constant study.
Executive summary:

In a GLP compliant dissociation constant study conducted in accordance with standardised guideline OECD 112, the dissociation constant of the test material was investigated. Under the conditions of the study, the test material was not observed to dissociate.

Description of key information

No dissociation of the test material was observed according to a study performed in line with OECD Guideline 112.

Key value for chemical safety assessment

Additional information

The key study (Malinksi, 1999) was performed in line with GLP and a standardised guideline with a sufficient level of detail to assess the quality of the study. The study was performed to a good standard and was assigned a reliability score of 1 using the principle for assessing data quality as set out in Klimisch (1997).