Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Endpoint:
bioaccumulation in aquatic species, other
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Prediction model
Title:
Bioaccumulation by Environmental Science Center’s PBT profiler
Author:
Environmental Science Center
Year:
2012
Bibliographic source:
PBT profiler, Office of Chemical Safety and Pollution Prevention , U.S. Environmental Protection Agency; version 1.301

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from PBT Profiler
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material : 4-fluorophenol
-Molecular Formula: C6H5FO
-Molecular weight: 112.1
-Physical state:solid
- Substance type: Organic
Radiolabelling:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
other: Fish

Study design

Route of exposure:
aqueous
Test type:
other: Estimation
Water / sediment media type:
not specified

Results and discussion

Bioaccumulation factor
Type:
BCF
Value:
6.8
Calculation basis:
other: Estimation

Applicant's summary and conclusion

Conclusions:
The estimated bioconcentration factor (BCF) for 4-fluorophenol is 6.8 which does not exceed the bioconcentration threshold of 1000. Thus it is concluded that 4-fluorophenol is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
Executive summary:

Bioaccumulation is the process by which the chemical concentration in an aquatic organism achieves a level that exceeds that in the water, as a result of chemical uptake through all possible routes of exposure. The relationship between bioaccumulation and bio-concentration is that, chemicals that have the potential to bioconcentrate also have the potential to bioaccumulate. Bioaccumulation is closely related to the Bioconcentration factor (BCF).

 

The estimated BCF of the key study was obtained to be 6.8.Supporting studies indicate the BCF to be between 3.5 to 3.8. This low value of BCF of 4-fluorophenol indicates its non bioaccumulative nature as the BCF factor is less than the bio-concentration threshold of 1000.