Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25.10.2012 to 06.11.2012
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Determination of ratio of concentrations of a compound in the two phases of a mixture of Octanol-Water at equilibrium
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
-Name of test material : 4-fluorophenol
- Molecular formula : C6H5FO
- Substance type: Organic
- Physical state: Solid

Results and discussion

Partition coefficient
Type:
Pow
Partition coefficient:
3.6
Temp.:
27 °C
pH:
4.36
Details on results:
Converting the above Pow value into its Log value, the Log Pow of 4-fluorophenol is 0.5563 at 27 degC and pH of 4.36

Applicant's summary and conclusion

Conclusions:
The experimental value of octanol water partition co-efficient (log Pow) of 4-fluorophenol is 0.5563 at 27 degC and pH of 4.36.This value indicates that 4-fluorophenol is relatively hydrophobic in nature.
Executive summary:

The experimental value of octanol water partition co-efficient (log Pow) of 4-fluorophenol is 0.5563 at 27 degC and pH of 4.36.This value indicates that 4-fluorophenol is relatively hydrophobic in nature.