Sodium 2-(2-dodecyloxyethoxy)ethyl sulphate

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Remarks:

Type of genotoxicity: gene mutation

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The read across chemical sodium lauryl sulphate has been identified as 80-90% structurally similar with target chemical sodium 2-(2-dodecyloxyethoxy) ethyl sulphate.This read across further screened in a two stage approach, first stage where in the generic categorisation is done based upon the functional group and mechanistic approach. In the second stage; the read across chemical is further screened based upon endpoint specific criteria. In addition, the target chemical and the read across substance have density and Log Kow values in a narrow range. Thus, they are expected to exhibit comparable toxic or alternatively non-toxic profile.

Data source

Reference

Reference Type:

publication

Title:

SALMONELLA MUTAGENICITY TESTS: II. RESULTS FROM THE TESTING OF 270 CHEMICALS

Author:

MORTELMANS,K, HAWORTH,S, LAWLOR,T, SPECK,W, TAINER,B AND ZEIGER,E

Year:

1986

Bibliographic source:

ENVIRON. MUTAGEN. 8(SUPPL. 7):1-119, 1986

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Principles of method if other than guideline:

Data is from ENVIRON. MUTAGEN.

GLP compliance:

not specified

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

Sodium dodecyl sulphate

EC Number:

205-788-1

EC Name:

Sodium dodecyl sulphate

Cas Number:

151-21-3

Molecular formula:

C12H25NaO4S

IUPAC Name:

sodium dodecyl sulfate

Details on test material:

- Name of test material : Sodium Lauryl Sulphate (sodium dodecyl sulphate)
- Substance type: Organic
- Physical state: Solid

Method

Species / strain

Species / strain / cell type:

S. typhimurium TA 100

Additional strain / cell type characteristics:

not specified

Metabolic activation:

without

Metabolic activation system:

S9

Test concentrations with justification for top dose:

3-333 UG/PLATE

Vehicle / solvent:

DISTILLED WATER

Results and discussion

Test results

Species / strain:

S. typhimurium TA 100

Metabolic activation:

without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not specified

Vehicle controls validity:

not specified

Untreated negative controls validity:

not specified

Positive controls validity:

not specified

Remarks on result:

other: all strains/cell types tested

Remarks:

Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information):
negative

Based on the experimental data for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium strain TA 100 without S9 metabolic activation it was estimated that sodium lauryl sulphate does not exhibit positive gene mutation effect.

Executive summary:

Based on the experimental data for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium strain TA 100 without S9 metabolic activation it was estimated that sodium lauryl sulphate does not exhibit positive gene mutation effect.