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EC number: 221-416-0 | CAS number: 3088-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of Sodium Lauryl Sulphate, Sodium Lauryl Ethoxysulphate and Corresponding Surfactants Derived from Synthetic Alcohols
- Author:
- A. I. T. WALKER, V. K. H. BROWN, L. W. FERRIGAN, R. G. PICKERING and D. A. WILLIAMS
- Year:
- 1 967
- Bibliographic source:
- Food Cosmetic. Toxicology. Vol. 5, pp, 763-769 1967
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Toxicity of Sodium Lauryl Sulphate was assessed in Rats in a 90 day study
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium dodecyl sulphate
- EC Number:
- 205-788-1
- EC Name:
- Sodium dodecyl sulphate
- Cas Number:
- 151-21-3
- Molecular formula:
- C12H25NaO4S
- IUPAC Name:
- sodium dodecyl sulfate
- Details on test material:
- - Name of test material : Sodium Lauryl Sulphate (sodium dodecyl sulphate)
- Molecular formula :NaC12H25SO4
- Molecular weight : 288.372
- Substance type: Organic
- Physical state : Solid
- Purity : 14% (sodium sulphate, sodium chloride, unsulphated feedstock and water)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth Farm 'E'
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age at study initiation: 5 wk
- Housing : individually caged
- Diet : Diet 86 powder ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: Diet 86 powder
- Details on oral exposure:
- DIET PREPARATION
- The test substance was mixed at various concentration in Diet 86 powder - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90 days (14 weeks)
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 40, 200, 1000 or 5000 ppm (0,2,10,50,250 mg/kg bw/day) respectively
Basis:
nominal in diet
- No. of animals per sex per dose:
- Control: 18 males and 18 females
40 ppm:
12 males and 12 females
200 ppm:
12 males and 12 females
etc - Control animals:
- yes, concurrent vehicle
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Daily observations were made on health
DETAILED CLINICAL OBSERVATIONS: Not determined
BODY WEIGHT: Yes
- Recorded weekly
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes
- Recorded weekly
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): Not determined
OPHTHALMOSCOPIC EXAMINATION: Not determined
HAEMATOLOGY: Yes
- Terminal blood samples were taken by cardiac puncture. Erythrocyte and leucocyte counts and determinations of Hematocrit and hemoglobin were made.
CLINICAL CHEMISTRY: Yes
- Total plasma protein and urea concentrations were determined, the serum protein fractions being determined by paper electrophoresis using LKB paper electrophoresis equipment
URINALYSIS: Yes
- Urine samples were obtained from the 5000 ppm and control groups during wk 12 on test by placing the rat in a metabolic cage for 16 hr and collecting the urine voided. The urine was examined for colour, pH, protein, reducing substances, bile salts and microscopic constituents.
NEUROBEHAVIOURAL EXAMINATION: Not determined - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
At autopsy, gross pathological examination was carried out and the major visceral organs were weighed
HISTOPATHOLOGY: Yes
Sections of a wide range of organs from rats of the 5000 ppm and control groups were processed for histological examination. - Statistics:
- Statistical analyses of terminal body weights, food intakes and organ weights were made using the initial body weight as a covariate in covariance analysis.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- effects observed, treatment-related
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Details on results:
- Clinical signs and mortality
Normal Health, behaviour was observed
Body weight and weight gain
Body weight remained within normal limits
Food consumption and compound intake
Food intake remained within normal limits
Food efficiency
Not determined
Ophthalmoscopic examination
Not Determined
Haematology
Haematological studies shows that the values of hemoglobin, Hematocrit, PVC, RBC WBC counts were within the normal limits
Clinical chemistry
Clinical chemical examinations of the blood revealed an increased serum urea concentration in females of high dose group
Urinanalysis
Urinary pH, color, protein, bile salts remained within the normal limits
Neurobehaviour
Not determined
Organ weights
Significant increases in absolute organ weights were confined to the highest dietary level but corresponding increases in relative organ weights did not attain statistical significance due to the non-significant increase in body weight
Gross pathology
At autopsy, no evidence of pathological change was obtained.
Histopathology
Spontaneous lesions, mainly hydronephrosis, were present in all groups of animals.
Details on results
Organ Weight:
The sulphates, C1 and D1, did not affect male organ weights, but C1 and D1 increased the liver weights and D1 the spleen and kidney weights of the 5000 ppm females.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: body weight, Organ weight, Clinical chemistry food intake, hematology, Urinalysis, gross pathology, Histopathology
- Dose descriptor:
- LOAEL
- Effect level:
- 250 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: body weight, Organ weight, Clinical chemistry food intake, hematology, Urinalysis, gross pathology,Histopathology
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The No Observed Adverse Effect Level (NOAEL) of Sodium Lauryl Sulphate in rat in a 90 day study was observed at a dose concentration of 50 mg/kg bw/day.
The Low Observed Adverse Effect Level (LOAEL) of Sodium Lauryl Sulphate in rat in the same study was observed at a dose concentration of 250 mg/kg bw/day. - Executive summary:
The purpose of this study was to evaluate the toxicity ofSodium Lauryl Sulphate in Carworth Farm 'E' Rats. In 90 days feeding study Carworth Farm 'E' Rats were administeredSodium Lauryl Sulphate at a dose concentration of0,40, 200, 1000 or 5000 ppm (0, 2, 10, 50 or 250 mg/kg bw/day) respectively. Body weight, organ weight, clinical chemistry food intake, hematology, urinalysis, gross pathology and histopathology were observed.
The health, behaviour, body weight and food intake, haematological and urinary findings were found within normal limits. There was an increase in serum urea concentration in females and inserum total protein concentration of males at higher dose. The organ weight and blood chemistry effects observed were unaccompanied by any pathological changes.
Hence,The No Observed Adverse Effect Level (NOAEL) andLow Observed Adverse Effect Level (LOAEL) was considered to be 50 and250 mg/kg bw/day, respectively.
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