Registration Dossier
Registration Dossier
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EC number: 221-416-0 | CAS number: 3088-31-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Inter-species variation in dermal reactivity
- Author:
- R. E. DAVIES, K. H. HARPER and S. R. KYNOCH
- Year:
- 1 972
- Bibliographic source:
- J. Soc. Cosmet Chem 23 371-381(1972)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- In vivo potential dermal irritancy of Sodium Lauryl Sulphate was assessed in rabbit after application for 24 hrs.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium dodecyl sulphate
- EC Number:
- 205-788-1
- EC Name:
- Sodium dodecyl sulphate
- Cas Number:
- 151-21-3
- Molecular formula:
- C12H25NaO4S
- IUPAC Name:
- sodium dodecyl sulfate
- Details on test material:
- - Name of test material : Sodium Lauryl Sulphate
- Molecular formula : NaC12H25SO4
- Molecular weight : 288.372
- Substance type : Organic
- Physical state : Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 1% and 5% concentration
- Duration of treatment / exposure:
- 24 hrs
- Observation period:
- 24 h and 72 h
- Number of animals:
- Groups of six rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 h and 72 h
- Score:
- 0.2
- Reversibility:
- no data
- Remarks on result:
- other: at 1% concentration
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 h and 72 h
- Score:
- 2
- Reversibility:
- no data
- Remarks on result:
- other: at 5% concentration
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The Primary Irritation Index (PII) score of Sodium Lauryl sulphate in New Zealand White Rabbit at 1% and 5% concentration was found to be 0.2 and 2 respectively.
- Executive summary:
Potential dermal irritancy of Sodium Lauryl Sulphate was assessed inNew Zealand Whiterabbit at1% and 5% concentrationfor 24 hrs.The Primary Irritation Index (PII) score was found to be 0.2 at 1 % and 2 at 5% concentration. From this score it is concluded that the substanceSodium Lauryl Sulphate is mildly irritating to rabbit.
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