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EC number: 221-416-0 | CAS number: 3088-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- THE IDENTIFICATION OF CONTACT ALLERGENS BY ANIMAL ASSAY. THE GUINEA PIG MAXIMIZATION TEST5
- Author:
- BERTIL MAGNUSSON, MD.t AND ALBERT M. KLIGMAN
- Year:
- 1 969
- Bibliographic source:
- THE JOURNAL OF INVESTIGATIVE DERMATOLOGY Copyright 1969 vol. 52, No. 3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Potential of Sodium lauryl sulphate to cause contact allergy was assessed in Albino guinea pigs by draize test
- GLP compliance:
- not specified
- Type of study:
- Draize test
- Justification for non-LLNA method:
- The study Albino guinea pigs by draize test is present which confirms the classification of the substacne so the new LLNA study was not conducted
Test material
- Reference substance name:
- Sodium dodecyl sulphate
- EC Number:
- 205-788-1
- EC Name:
- Sodium dodecyl sulphate
- Cas Number:
- 151-21-3
- Molecular formula:
- C12H25NaO4S
- IUPAC Name:
- sodium dodecyl sulfate
- Details on test material:
- - Name of test material : Sodium dodecyl Sulphate
- Molecular formula : NaC12H25SO4
- Molecular weight : 288.372
- Substance type : Organic
- Physical state : Solid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals and environmental conditions:
- - Weight at study initiation : 300-500 gram
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- physiological saline
- Concentration / amount:
- 0.1ml of 0.1% solution of Sodium lauryl sulphate
Challengeopen allclose all
- Route:
- intradermal
- Vehicle:
- physiological saline
- Concentration / amount:
- 0.1ml of 0.1% solution of Sodium lauryl sulphate
- No. of animals per dose:
- 25
- Details on study design:
- A. INDUCTION EXPOSURE
- No. of exposures: 10 exposures
- Exposure period: 2 weeks
- Test groups:
- Control group: no data
- Site: intradermal injection
- Frequency of applications: Daily
- Duration: 2 weeks
- Concentrations: 0.1 ml
B. CHALLENGE EXPOSURE
- No. of exposures: one exposure
- Day(s) of challenge: After 2weeks of induction exposure
- Exposure period: 24 hrs
- Test groups:
- Control group: No data
- Site: intradermal injection
- Concentrations: 0.05 ml
- Evaluation (hr after challenge): 24 hrs
OTHER:
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.1 ml induction exposure, 0.05 ml challenge exposure
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.1 ml induction exposure, 0.05 ml challenge exposure . No with. + reactions: 0.0. Total no. in groups: 25.0.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance Sodium lauryl sulphate was found to be weakly sensitizing to Hartley Albino guinea pigs in 2 weeks study by standard Draize test
- Executive summary:
The standard Draize test was carried out todetermine the sensitization potential of Sodium lauryl sulphate. 0.1 ml solution of sodium lauryl sulphate was injected intradermally to 3 to 4 cms square area of skin. The application was repeated every other or three time a week for a total of ten. The site was read 24 hours after each injection. Two weeks after the 10th injection, the animals were challenged by an intradermal injection of 0.05 ml into a fresh skin area. The animal was judged to be sensitized if the reaction was clearly greater than the average reaction of the inducing injections. Sodium lauryl sulphate was found to be weakly sensitizing to skin of guinea pig with score of 1.
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