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EC number: 221-416-0 | CAS number: 3088-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- DERMAL TOXICITY OF SODIUM LAURYL SULFATE
- Author:
- STEVEN CARSO, BERNARD L. OSER
- Year:
- 1 964
- Bibliographic source:
- J. soc. cos. CHEM. 15, 137-147 (1964)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Acute dermal toxicity of Sodium lauryl sulphate was assessed in Rabbits.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium dodecyl sulphate
- EC Number:
- 205-788-1
- EC Name:
- Sodium dodecyl sulphate
- Cas Number:
- 151-21-3
- Molecular formula:
- C12H25NaO4S
- IUPAC Name:
- sodium dodecyl sulfate
- Details on test material:
- - Name of test material : Sodium Dosecyl Sulphate
- Molecular formula : NaC12H25SO4
- Molecular weight : 288.372
- Substance type : Organic
- Physical state : Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- other: Intact and abraded skin
- Vehicle:
- water
- Details on dermal exposure:
- Sodium lauryl sulfate (SLS) was dissolved in water to make slurry
- Duration of exposure:
- 24 hrs
- Doses:
- 150, 300, 600, 1200, 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration : two-weeks period
- Other examinations performed : Gross pathological changes were noted. Mean primary irritation score, body weight changes and appearance of the skin at the site of application after 14 days was also noted.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 580 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality was observed
- Clinical signs:
- other: Slight scaling and wrinkling of skin was also observed
- Gross pathology:
- Tremors, tonic-clonic convulsions and respiratory failure were characteristically seen
- Other findings:
- Primary irritation score obtained after 24 to 72 hrs of application varies from 3 to 4.2
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The Acute dermal LD50 value of Sodium Lauryl sulphate in rabbit was observed at dose concentration of 580 + 138 mg/kg body weight
- Executive summary:
The purpose of this study was to evaluate the dermal toxicity of Sodium lauryl sulphate, 33% slurry of Sodium lauryl sulphate in water was administered on tointact and abraded skin of rabbit at dose concentration of 150, 300, 600, 1200, 2000 mg/kg bw for 24 hrs and observed for 2 weeks,the mean maximum primary skin irritation score and their body weights were recorded. All that died and the survivors at 14 days were necropsied and gross pathological changes were noted.
Mortalities were observed between 20 to 40 %. Slight scaling and wrinkling of skin was observed.Tremors, tonic-clonic convulsions and respiratory failure were characteristically seen.Primary irritation score obtained after 24 to 72 hrs of application varies from 3 to 4 with the LD50 value of580+138 mg/kg body weight.
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