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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species, other
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Estimated data generated using the EPI Suite program developed by the USEPA.
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
Prediction done using BCFBAF (v3.01) model
GLP compliance:
not specified
Radiolabelling:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
natural water: freshwater
Test temperature:
25 deg.C
Reference substance (positive control):
not specified
Temp.:
25 °C
Type:
BCF
Value:
3.162 L/kg
Basis:
whole body w.w.
Calculation basis:
other: estimated
Remarks on result:
other: Non-bioaccumulative
Validity criteria fulfilled:
not specified
Conclusions:
Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical is nonbioaccumulative in food chain.
Executive summary:

Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical  is nonbioaccumulative in food chain.

Description of key information

Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical  is nonbioaccumulative in food chain.

Key value for chemical safety assessment

BCF (aquatic species):
3.162 L/kg ww

Additional information

Predicted data study and experimental studies were reviewed from different authoritative database for bioconcentration factor endpoint and their results are summarized below.

The first study was done by using BCFBAF Program (v3.00) model of EPI suite (2018) in this study the estimated bio concentration factor (BCF) for test chemical was 3.162 L/kg wet-wt at 25 deg. c

Next study was experimental study reviewed fromauthoritative database ( J check) in this study the Bioaccumulation test was conducted for 28 days for estimating the bioconcentration factor (BCF) and lipid content of test substance in test organism Cyprinus carpio. The Nominal concentrations used in the study are 1stconcentration area: 0.46 mg/l 2ndconcentration area: 0.046 mg/l. Range finding study was carried out onRice fish (Oryzias latipes) and the 96 hr LC50 value was determined to be >200mg/l.By analytical methods, the limit of quantification was Test water: 1stconcentration area: 11 µg/l 2ndconcentration area: 1.1 µg/l Fish: 120 ng/g The lipid content at the start and end of exposure was found to be 2.94% and 4.14%, respectively.The test substance concentration in environment during a period of 28 days was 0.46 mg/l, 0.046 mg/l and bioconcentration (BCF) value of test substance was determined to be ≤ 0.27 l/kg, respectively. Thus, the test substance has a low potential of bioaccumulation in test organism Cyprinus carpio during 28 day period.

Another study was reviwed from authoritative database (HSDB) in this study the Bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical. The bioconcentration factor was determined to be 75 dimesionless, from an estimated log Pow of -0.67 and a regression derived equation. This suggests that the potential for bioconcentration of test substance in aquatic organisms is low.

Last study was also reviewed from authoritative database (J check) in this study the Bioaccumulation experiment was conducted on test organism Cyprinus carpio for 28 days for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed according to OECD Guideline 305 (Bioconcentration: Flow-through Fish Test) and other guideline"Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study were1.69 mg/land 0.169 mg/l, respectively. Analytical method involve the recovery ratio:Fish : 89.6 % - Limit of quantitation : Test water : 1st concentration area : 83 microg/L 2nd concentration area : 8.3 microg/L Fish: 940 ng/g. Range finding study involve the LC50(96h) > 200 mg/LonRice fish (Oryzias latipes). Lipid content of the test organism Cyprinus carpio was determined to be 5.09% and 6% at the start and end of the exposure. The bioconcentration factor (BCF value) of test substance on Cyprinus carpio was determined to be≤ 0.57 L/Kg at a conc. of 1.69 mg/l and ≤ 5.3 L/Kg at a conc. of 0.169 mg/l, respectively.

By considering results of all the studies mentioned above it can be concluded that test chemical is non-bioaccumulative in aquatic organisms