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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as-
2. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
1. Structure estimation method
2. No data available
Remarks:
1. The study was performed at pH 7.0 and 8.0, respectively.
Remarks:
2. The study was performed at pH range7.4 to 7.8 & 20.1 to 20.5⁰C,respectively. Test chemical conc. measured were 0.0287, 0.0320, 0.0334, 0.0349, 0.0251, 0.0311, 0.0414, 0.0370, 0.0362 & 0.0363 mg/l at 0, 1, 3, 6, 8, 10, 13, 15, 17 & 20 days,respectively.
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
pH:
7
DT50:
48 yr
Type:
second order
Remarks on result:
other: 2. Hydrolysis rate constant of test chemical is 0.0046 L/mol-sec.
pH:
8
DT50:
5 yr
Type:
second order
Remarks on result:
other: 3. Hydrolysis rate constant of test chemical is 0.0046 L/mol-sec.
Remarks on result:
other: 3. Although half-life value of chemical was not known, but based on the measured concentration of test chemical in water, chemical appears to be in equilibrium and does not appear to be breaking down in water.
Details on results:
2. The half-life value of test chemical was determined to be 48 yrs and 5 yrs at pH 7 and 8, respectively and thus test chemical was reported to be hydrolytically stable.
3. Based on the measured concentration of test chemical in water, chemical was reported to be hydrolytically stable at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C for 20 days. Test chemical appears to be in equilibrium and does not appear to be breaking down in water. The concentration of test chemical is not decreasing with time.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 48 yrs and 5 yrs at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.0046 L/mol-sec, respectively or > 20 days at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical . The studies are as mentioned below:

The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.0046L/mol-sec with a corresponding half-lives of 48 yrs and 5 yrs at pH 7 and 8, respectively. Based on the half-life value, it is concluded that the test chemical is not hydrolysable.

The half-life of the test chemical was determined at different pH range. The study was performedat apH range7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively.The test substance was dissolved in dechlorinated tap water. The concentration of the test substance was measured in the supernatant of the test solution centrifuged. The test substance was measured on day 0, 1, 3, 6, 8, 10, 13, 15, 17, and 20 over a 21-day period. The test concentration used was considered to be at saturation in water. Based on the measured concentration of test chemical in water, chemical was reported to be hydrolytically stable at pH range7.4 to 7.8 and a temperature of 20.1 to 20.5 ⁰C for 20 days. Test chemical appears to be in equilibrium and does not appear to be breaking down in water. The concentration of test chemical is not decreasing with time. Thus, the half-life value of test chemical was determined to be > 20 days and on the basis of this, test chemical is considered to be not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 48 yrs and 5 yrs at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.0046 L/mol-sec, respectively or > 20 days at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical  can be expected to be 48 yrs and 5 yrs at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.0046 L/mol-sec, respectively or > 20 days at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical  is not hydrolysable.

Key value for chemical safety assessment

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical . The studies are as mentioned below:

The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.0046L/mol-sec with a corresponding half-lives of 48 yrs and 5 yrs at pH 7 and 8, respectively. Based on the half-life value, it is concluded that the test chemical is not hydrolysable.

The half-life of the test chemical was determined at different pH range. The study was performedat apH range7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively.The test substance was dissolved in dechlorinated tap water. The concentration of the test substance was measured in the supernatant of the test solution centrifuged. The test substance was measured on day 0, 1, 3, 6, 8, 10, 13, 15, 17, and 20 over a 21-day period. The test concentration used was considered to be at saturation in water. Based on the measured concentration of test chemical in water, chemical was reported to be hydrolytically stable at pH range7.4 to 7.8 and a temperature of 20.1 to 20.5 ⁰C for 20 days. Test chemical appears to be in equilibrium and does not appear to be breaking down in water. The concentration of test chemical is not decreasing with time. Thus, the half-life value of test chemical was determined to be > 20 days and on the basis of this, test chemical is considered to be not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 48 yrs and 5 yrs at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.0046 L/mol-sec, respectively or > 20 days at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.