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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1967-08-17 to 1967-08-28
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifially acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report Date:
1967

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
only 7 days observation period
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: US rats
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
The test substance was administered in concentrations of 2, 4, 8 and 20% (V/V).
Doses:
160, 200, 256, 320, 640, 1280 mg/kg
No. of animals per sex per dose:
10 per dose level
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
ca. 280 mg/kg bw
Based on:
test mat.
Remarks on result:
other: original value: ca. 0.35 mL/kg; the LD50 value was calculated using a densitiy of 0.8003 g/mL (at 20 °C)
Mortality:
160, 200 and 256 mg/kg: no deaths; 320: 8/10 after 7 days; 640 and 1280 mg/kg: 10/10 after 7 days
Clinical signs:
Dyspnea, spasms, abdominal and lateral position, cyanosis and apathy were observed.
Body weight:
Nothing abnormal detected.
Gross pathology:
Nothing abnormal detected.

Applicant's summary and conclusion