Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report Date:
1967

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
Name of the test substance used in the study report: Methylpyrrolidin

Test animals

Species:
mouse
Strain:
other: Kisslegg mice
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
Test concentrations used were 1, 2 and 20% (v/v).
Doses:
40, 100, 128, 160, 1280 mg/kg (original values 50, 100, 125, 160, 200, 1600 mm3/kg, values in mg/kg calculated using a density of 0.8003 g/mL)
No. of animals per sex per dose:
10 per dose level
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 88 mg/kg bw
Based on:
test mat.
Remarks on result:
other: original value: ca. 0.11 mL/kg, value in mg/kg bw was calculated using the densitiy of 0.8003 g/mL (at 20 °C)
Mortality:
40 mg/kg: no deaths; 80 mg/kg: 1/10 after 7 days; 100, 128, 160 and 1280 mg/kg: 10/10 after 7 days
Clinical signs:
dyspnea, spasms, abdominal and lateral position, cyanosis, apathy
Body weight:
no data
Gross pathology:
adherences and adhesions in the abdomen

Applicant's summary and conclusion