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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-methylpyrrolidine
EC Number:
204-438-5
EC Name:
1-methylpyrrolidine
Cas Number:
120-94-5
Molecular formula:
C5H11N
IUPAC Name:
1-methylpyrrolidine
Test material form:
other: liquid
Details on test material:
Name of the test substance used in the study report: Methylpyrrolidin

Test animals

Species:
mouse
Strain:
other: Kisslegg mice
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
Test concentrations used were 1, 2 and 20% (v/v).
Doses:
40, 100, 128, 160, 1280 mg/kg (original values 50, 100, 125, 160, 200, 1600 mm3/kg, values in mg/kg calculated using a density of 0.8003 g/mL)
No. of animals per sex per dose:
10 per dose level
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 88 mg/kg bw
Based on:
test mat.
Remarks on result:
other: original value: ca. 0.11 mL/kg, value in mg/kg bw was calculated using the densitiy of 0.8003 g/mL (at 20 °C)
Mortality:
40 mg/kg: no deaths; 80 mg/kg: 1/10 after 7 days; 100, 128, 160 and 1280 mg/kg: 10/10 after 7 days
Clinical signs:
dyspnea, spasms, abdominal and lateral position, cyanosis, apathy
Body weight:
no data
Gross pathology:
adherences and adhesions in the abdomen

Applicant's summary and conclusion