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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014-04-24
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP and Guideline Study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report Date:
2014

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
Version / remarks:
2006
Deviations:
no
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test system

Controls:
other: not applicable
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): appr. 500 μL
Duration of treatment / exposure:
not applicable
Observation period:
not applicable
Number of animals:
not applicable

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
other:
Value:
2.34
Remarks on result:
other:
Remarks:
Basis: other: mean of 7 vials. Time point: break through times. (migrated information)

In vivo

Irritant / corrosive response data:
Corrosive potential was determined on the basis of the average time recorded for the test substance to produce a change in the CDS.

Applicant's summary and conclusion

Interpretation of results:
Category 1A (corrosive)
Remarks:
Migrated information Criteria used for interpretation of results: EU