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EC number: 205-575-3 | CAS number: 142-96-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1954
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well performed study, study performance before , implementation of GLP, purity of test item not reported.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data, List V
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C.
- Year:
- 1 954
- Bibliographic source:
- Arch. Ind. Hyg. Occup. Med., 10, 61-68
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Study conducted prior to guidelines but study conduct comparable to current OECD TG 402
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dibutyl ether
- EC Number:
- 205-575-3
- EC Name:
- Dibutyl ether
- Cas Number:
- 142-96-1
- Molecular formula:
- C8H18O
- IUPAC Name:
- 1-butoxybutane
- Details on test material:
- dibutyl ether (purity not indicated)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 -3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: no vehicle used
- Details on dermal exposure:
- The fur was closely clipped over the entire trunk, and the doses, retained beneath an impervious plastic film, the exposure area corresponded to about 1/10 of the body surface. After 24 hours of contact the film was removed.
- Duration of exposure:
- 24 hours
- Doses:
- no information available
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- The acute dermal toxicity of dibutyl ether for rabbits was estimated by the technique of Draize et al. (1944), using groups of four male New Zealand giant albino rabbits weighing 2.5 to 3.5 kg. The fur was closely clipped over the entire trunk, and the doses, retained beneath an impervious plastic film, the exposed area corresponding to about 1/10 of the body surface. After 24 hours of contact the film was removed. Animals were observed for mortality fourteen days after dosing. Clinica;l signs were not reported.
- Statistics:
- The most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947) using the tables of Weil (1952)
Results and discussion
- Preliminary study:
- not applicable
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10.08 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 4.41 - 23.04
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 7 741 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 387 - 17 695
- Mortality:
- no information available
- Clinical signs:
- other: no information available
- Gross pathology:
- no information available
- Other findings:
- no information available
Any other information on results incl. tables
Original values given by the authors in ml/kg bw: LD50 (95 % C.I.) 10.08 (4.41 - 23.04) ml/kg bw, which is equal to 7741 (3387 - 17695) mg/kg bw (density of dibutyl ether: 0.768 g/cm³).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the LD50 of dibutyl ether was 10.8 ml/kg; which is equal to 7741 (3387 - 17695) mg/kg body weight to rabbits, therefore this substance is not classified.
- Executive summary:
In this study, the acute dermal toxicity of dibutyl ether for rabbits was estimated by the technique of Draize et al. (1944), using groups of four male New Zealand giant albino rabbits weighing 2.5 to 3.5 kg. The fur was closely clipped over the entire trunk, and the doses, retained beneath an impervious plastic film, the exposed area corresponding to about 1/10 of the body surface. After 24 hours of contact the film was removed. Animals were observed for mortality for fourteen days after dosing. The most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947) using the tables of Weil (1952). Clinical signs were not reported.
Under the conditions of the study, the LD50 of dibutyl ether was 10.8 ml/kg; which is equal to 7741 (3387 - 17695) mg/kg body weight to rabbits, therefore this substance is not classified.
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