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EC number: 205-575-3 | CAS number: 142-96-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1943
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Short report only, no details available
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Sensory response to certain industrial solvent vapors
- Author:
- Nelson, K.W., Ege, J.F. Jr., Ross, M., Woodman, L.E., Silverman, L.
- Year:
- 1 943
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 28 (7) 282-285
- Reference Type:
- publication
- Title:
- Further studies on sensory response to certain industrial solvent vapors
- Author:
- Silverman, L., Schulte, H.F., First, M.W.
- Year:
- 1 946
- Bibliographic source:
- J. Ind. Hyg. Toxicol., 28, 262-266
Materials and methods
- Type of study / information:
- Type of experience: other: Sensory irritant properties on humans
- Endpoint addressed:
- not applicable
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The objective of this experiment was to evaluate the unplesant effects of solvent vapours on huma subjects
- GLP compliance:
- no
Test material
- Reference substance name:
- Dibutyl ether
- EC Number:
- 205-575-3
- EC Name:
- Dibutyl ether
- Cas Number:
- 142-96-1
- Molecular formula:
- C8H18O
- IUPAC Name:
- 1-butoxybutane
- Details on test material:
- no information available
Constituent 1
Method
- Ethical approval:
- no
- Details on study design:
- In a 1200 cubic foot gas cabinet an average number of 12 persons, of mixed sexes, was exposed to a given concentration of solvent vapor for a period of 15 minutes. After the exposure, each individual classified the effect of the vapor on the eyes, nose, and throat. The classifications possible were: no reaction, slight irritating, and very irritating. The odor was listed as absent, definite, moderate, strong, or overpowering. Finally each person was asked if he believed he could work in the atmosphere for an eight-hour day. The subjects, except the experimenters, were kept in ignorance of the actual concentrations and whether or not the exposures to any one solvent were in order of increasing or decreasing concentrations. The amount of vapor which the majority of subjects rejected as a working atmosphere was termed objectionable
- Exposure assessment:
- not specified
- Details on exposure:
- In a 1200 cubic foot gas cabinet an average number of 12 persons, of mixed sexes, was exposed to a given concentration of solvent vapor for a period of 15 minutes. After the exposure, each individual classified the effect of the vapor on the eyes, nose, and throat. The classifications possible were: no reaction, slight irritating, and very irritating. The odor was listed as absent, definite, moderate, strong, or overpowering. Finally each person was asked if he believed he could work in the atmosphere for an eight-hour day. The subjects, except the experimenters, were kept in ignorance of the actual concentrations and whether or not the exposures to any one solvent were in order of increasing or decreasing concentrations. The amount of vapor which the majority of subjects rejected as a working atmosphere was termed objectionable
Results and discussion
- Results:
- Under the conditions of the study, 200 ppm (app. 1066 mg/m³) were sensory irritating to the eyes and the nose but not to the throat of a majority of subjects. At 300 ppm (app. 1599 mg/m³) the odor was not objectionable to the majority of subjects.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the study, 200 ppm (app. 1066 mg/m³) were sensory irritating to the eyes and the nose but not to the throat of a majority of subjects. At 300 ppm (app. 1599 mg/m³) the odor was not objectionable to the majority of subjects.
- Executive summary:
The objective of the experiment was to evaluate on humans the unpleasant, not necessarily toxic, effects of solvent vapors. In a 1200 cubic foot gas cabinet an average number of 12 persons, of mixed sexes, was exposed to a given concentration of solvent vapor for a period of 15 minutes. After the exposure, each individual classified the effect of the vapor on the eyes, nose, and throat. The classifications possible were: no reaction, slight irritating, and very irritating. The odor was listed as absent, definite, moderate, strong, or overpowering. Finally each person was asked if he believed he could work in the atmosphere for an eight-hour day. The subjects, except the experimenters, were kept in ignorance of the actual concentrations and whether or not the exposures to any one solvent were in order of increasing or decreasing concentrations. The amount of vapor which the majority of subjects rejected as a working atmosphere was termed objectionable
Under the conditions of the study, 200 ppm (app. 1066 mg/m³) were sensory irritating to the eyes and the nose but not to the throat of a majority of subjects. At 300 ppm (app. 1599 mg/m³) the odor was not objectionable to the majority of subjects.
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