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Diss Factsheets

Administrative data

Description of key information

OECD 404:  C4 Acrylate was not a skin irritant
OECD 405: C4 Acrylate was not an eye irritant

Key value for chemical safety assessment

Additional information

The primary skin irritation/corrosion potential of C4 acrylate was assessed in the rabbit (4-hour semi-occlusive application). The study was carried out based on the guidelines described in EC Commission Directive 92/69/EEC, B.4 and OECD No. 404. Three male rabbits were exposed to 0.5 grams of the test article, applied onto clipped skin for 4 hours using a semi-occlusive dressing. Observations were made 1, 24, 48 and 72 hours after exposure. No mortality, systemic toxicity, corrosive effects or skin irritation was caused by 4 hours exposure to the test article. Based on the results of this study and according to the EC criteria for classification and labelling requirements (CLP Regulation No 1272/2008), the test substance does not have to be classified and has no obligatory labeling requirement for skin irritation.


The eye irritation potential of C4 Acrylate was evaluated in 3 male rabbits. The study was carried out based on the following guidelines: OECD 405 and EC Commission Directive 92/69/EEC. Single samples of approximately 55 mg of the test article (volume of 0.1 ml) were instilled into one eye of each of three rabbits. Observations were made 1, 24, 48 and 72 hours and 7 days after instillation. The test substance caused irritation of the conjunctivae, shown as redness, chemosis and discharge. The irritation was and completely resolved within 72 hours in one animal and within 7 days in the other animals. Remnants of the test substance were present in the eyes of all animals on day 1. Based on the results of the study, the test article has no obligatory labelling requirement for eye irritation according to EC criteria for classification and labelling requirements (CLP Regulation No 1272/2008).

Justification for classification or non-classification

The test results for in the skin and eye Irritation studies do not meet the criteria for classification as a skin or eye irritant.