Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

The contact hypersensitivity potential of T-7600, C4 -Acrylate, in the Albino Guinea Pig (Maximisation Test) was assessed in Dunkin Hartley Guinea Pigs. This study was based on the guidelines described in OECD No. 406., EC Commission Directive 96/54/EC, EPA OPPTS 870.2600. The test substance concentrations used in the main study were based on the results of a preliminary study. In the main study, ten experimental animals were intradermally injected with a 2% concentration and epidermally exposed to a 50% concentrations of the test article. Five control animals were similarly treated, but with the vehicle alone (corn oil). Approximately 24 hours before the epidermal induction exposure all animals were treated with 10% SDS. Two weeks after the epidermal application all animals were challenged with a 50% test substance concentration and the vehicle. In the challenge phase, skin reactions varied between grades 1 and 3 were observed in all experimental animals in response to the 50% test substance concentration. No skin reactions were evident in the control animals. Scaliness was seen in some treated skin sites among the experimental animals. The skin reactions observed in response to a 50% test substance concentration in all ten experimental animals in the challenge phase were considered indicative of sensitization (sensitization rate of 100).

Migrated from Short description of key information:
C4- Acrylate was tested in a Guinea Pig Maximization Test and was considered to be a sensitizer.

Justification for classification or non-classification

The test results for in the GPMT meet the criteria for classification as a sensitizer, Skin Sens. Cat 1B according 2ndATP of the CLP Regulation.