Registration Dossier
Registration Dossier
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EC number: 266-733-5 | CAS number: 67584-55-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
The contact hypersensitivity potential of T-7600, C4 -Acrylate, in the Albino Guinea Pig (Maximisation Test) was assessed in Dunkin Hartley Guinea Pigs. This study was based on the guidelines described in OECD No. 406., EC Commission Directive 96/54/EC, EPA OPPTS 870.2600. The test substance concentrations used in the main study were based on the results of a preliminary study. In the main study, ten experimental animals were intradermally injected with a 2% concentration and epidermally exposed to a 50% concentrations of the test article. Five control animals were similarly treated, but with the vehicle alone (corn oil). Approximately 24 hours before the epidermal induction exposure all animals were treated with 10% SDS. Two weeks after the epidermal application all animals were challenged with a 50% test substance concentration and the vehicle. In the challenge phase, skin reactions varied between grades 1 and 3 were observed in all experimental animals in response to the 50% test substance concentration. No skin reactions were evident in the control animals. Scaliness was seen in some treated skin sites among the experimental animals. The skin reactions observed in response to a 50% test substance concentration in all ten experimental animals in the challenge phase were considered indicative of sensitization (sensitization rate of 100).
Migrated from Short description of key information:
C4- Acrylate was tested in a Guinea Pig Maximization Test and was considered to be a sensitizer.
Justification for classification or non-classification
The test results for in the GPMT meet the criteria for classification as a sensitizer, Skin Sens. Cat 1B according 2ndATP of the CLP Regulation.
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