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EC number: 272-712-1 | CAS number: 68909-77-3 The residuum from the reaction of diethylene glycol and ammonia. It consists predominantly of morpholine-based derivatives such as [(aminoethoxy)ethyl]morpholine, [(hydroxyethoxy)ethyl]morpholine, 3-morpholinone, and 4,4'-(oxydi-2,1-ethanediyl)bis[morpholine].
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable calculation method
- Specific details on test material used for the study:
- - sponsor's identification: Amine C8
- Description: dark brown liquid
- Batch number: T7-271109
- Date received 21 September 2010
- Expiry date: 31 December 2011
- Storage conditions: room temperature in the dark - Test organisms (species):
- Daphnia magna
- Water media type:
- freshwater
- Dose descriptor:
- NOEC
- Effect conc.:
- > 1 mg/L
- Remarks on result:
- other: expected NOEC based on ACR approach
- Conclusions:
- table 40, 41, 43: expected NOEC >1 mg/L
table 42, 45: expected NOEC >1 mg/L
Reference
Acute:Chronic Ration approach
Source |
Description |
ACR (90%-ile) |
Expected NOEC (mg/L): EC50 (> 100 mg/L) / ACR |
Table 40 |
All species (geometric mean) |
71 |
> 1 |
Table 40 |
All invertebrates (geometric mean) |
79 |
>1 |
Table 41 |
All species (individual species) |
71.2 |
>1 |
Table 41 |
All invertebrates (individual species) |
94.5 |
> 1 |
Table 42 |
Mode of action (narcotic) (*) |
11.5 |
(>1) |
Table 43 |
Invertebrates (Daphnia magna) |
44 |
>1 |
Table 45 |
Daphnia magna / organics |
20 |
>1 |
*not applicable for secondary amines
- short term toxicity test on invertebrates: EC50 (48 h) mg/L: >100 mg/L
- conclusion:
table 40, 41, 43: expected NOEC >1 mg/L
table 42, 45: expected NOEC >1 mg/L
Description of key information
Key value for chemical safety assessment
Additional information
In Annex IX Section 9.1.5 column 2 of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing on aquatic invertebrates shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on invertebrates. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or CLP-Regulation (EC) No 1272/2008 or is assessed to be a PBT or vPvB. The hazard assessment of the substance reveals that the substance is not a PBT, nor a vPvB substance. In Annex XI Section 3, it is laid down that testing in accordance with sections 8.6 and 8.7 of Annex VIII and in accordance with Annex IX may be omitted, based on the exposure scenario(s) developed in the Chemical Safety Report. In accordance with Annex XI Section 3, it can be demonstrated in the risk assessment that the manufacture and the intermediate use of the substance do not pose an unacceptable risk for all environmental compartments as the risk characterization ratios (RCRs) of the chemical safety assessment are below 1 for all compartments (see Chemical Safety Report Ch. 10). Therefore, a long-term toxicity test on aquatic invertebrates is not provided.
In addition, the acute-to-chronic ratio (ACR) as determined following the ECETOC Technical Report No. 93 (Aquatic Hazard Assessment II; ECETOC, 2003) shows that a long-term NOEC for daphnids of > 1 mg/L is to be expected.
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