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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05/12/2014 to 05/16/2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 20131219
Key result
Water solubility:
0.224 µg/L
Temp.:
20 °C
Remarks on result:
other: no other data available.

Individual Results:

Preliminary Visual Estimation of the Water Solubility:

The preliminary visual experiments showed that the water solubility of the test item is very low as 10 mg test item could not be dissolved in 50 ml water.

Flask-Method

Table: Water solubility of the test item – experiments A to D

 Experiment  A  B  C  D (Blank)
 Amount of test item (mg)  500  500  500  -
 Stirring time at 30°C (h)  24  48  72  72
 Measured concentration (μg/ml)  0.000224  0.000224  0.000224  n.d.
 Water solubility (μg/l)  0.224

 0.224

 0.224  -

Average experiments A to C: 0.224 μg/l

Table: Standard addition for recheck

 Standard

 Measured concentration (μg/ml)

% Recovery 

 Sample C + 0.98 μg test item

0.97 

98.9 

The recovery of 98.9 % indicates a sufficient accuracy of the analytical method.

Conclusions:
The water solubility of FAT 93503/B at a temperature of 20 °C was determined to be 0.224 μg/l.
Executive summary:

The water solubility of FAT 93503/B was determined in a study conducted according to OECD Guideline 105 and EU Method A.6. In the first step, preliminary estimation of water solubility was estimated visually, which was determined to be low as 10 mg test substance could not be dissolved upto 50 ml water. Hence, the flask method was used for the main experiment. Based on the findings of this stage, the water solubility for FAT 93503/B was determined to be 0.224 μg/l.

Description of key information

The water solubility of FAT 93503/B was determined in a study conducted according to OECD Guideline 105 and EU Method A.6. In the first step, preliminary estimation of water solubility was estimated visually, which was determined to be low as 10 mg test substance could not be dissolved upto 50 ml water. Hence, the flask method was used for the main experiment. Based on the findings of this stage, the water solubility for FAT 93503/B was determined to be 0.224 μg/l.

Key value for chemical safety assessment

Water solubility:
0.224 µg/L
at the temperature of:
20 °C

Additional information