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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05/12/2014 to 05/16/2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 20131219
Analytical method:
other: using UV- Perkin Elmer Lambda 25 equipment
Key result
Type:
log Pow
Partition coefficient:
6.39
Temp.:
20 °C
Remarks on result:
other: pH not available
Details on results:
Calculation of the partition coefficient log Pow from the individual solubility in waer and n-octanol:
By means of the flask method, the saturation concentration of the test item in n-octanol was determined to: 548 mg/l.
By means of the flask method, the saturation concentration of the test item in water was determined to: 0.224 μg/l
Conclusions:
The partition coefficient n-octanol/water (log Pow) of FAT 93503/B at 20 °C was determined to be 6.39.
Executive summary:

The n-octanol /water partition coefficient of FAT 93503/B was determined in a study conducted according to OECD Guideline 107 and EU A.8 method. The determination was achieved by using the Shake Flask Method. Based on the findings of the study, the partition coefficient n-octanol/water (log Pow) of the test item at 20 °C was determined to be 6.39.

Description of key information

The n-octanol /water partition coefficient of FAT 93503/B was determined in a study conducted according to OECD Guideline 107 and EU A.8 method. The determination was achieved by using the Shake Flask Method. Based on the findings of the study, the partition coefficient n-octanol/water (log Pow) of the test item at 20 °C was determined to be 6.39.

Key value for chemical safety assessment

Log Kow (Log Pow):
6.39
at the temperature of:
20 °C

Additional information