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EC number: 229-355-1
CAS number: 6486-23-3
The test item was assessed for its possible contact allergenic potential
in a local lymph node assay according to OECD TG 429. The test was
performed using test item concentrations of 5, 10 and 20% (w/v). The
animals (5 female mice/dose group) did not show any clinical signs
during the course of the study and no cases of mortality were observed.
In this study Stimulation Indices (S.I.) of 1.4, 1.6 and 1.9 were
determined with the test item at concentrations of 5, 10 and 20% (w/v)
in DMSO, respectively. The results obtained with the positive control
confirmed the validity of the test. The test item was not a skin
sensitiser under the conditions tested.
The animals did not show any clinical signs during the course of the
study and no cases of mortality were observed. Due to the intense yellow
colour of the test item local irritation reactions such as ear redness
could not be detected. The body weight of the animals was within the
normal range. Calculation of the EC3 value was not performed, because no
test concentration produced a SI of 3 or higher.
The test item did not caus skin sensitisation in a LLNA study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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