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EC number: 229-355-1
CAS number: 6486-23-3
Disposition of PY 74 (values in table given represent the mean % of dose
for three rats (SD in brackets)):
* the amounts present in urine samples were included in the values for
faeces, because the authors concluded that the small amounts in urine
were probably due to contamination of urine by faeces
** only values for two rats in this group
Results were described by the authors as follows:
One and four hours after dosing most of the administered material was
present in the gut contents and none was in the faeces. Twenty four and
48 after dosing, most substance was in the faeces. Detectable amounts
were only in those tissues directly in contact with the compound. No
compound was found in samples of plasma, whole blood, liver, kidney, or
lungs, even after administration of doses ten times larger (data not
The authors concluded that the small quantities of componds present in
samples of tissues that were in direct contact with the substance can be
attributed to mechanical adherance to the tissues rather than to
Recoveries of the pigment was nearly complete.
Male Fischer 344 rats received 12.6 or 126 mg/kg test item by gavage. Twenty four and 48 hours after dosing most part of the substance was detected in the faeces (up to 86%). Only minor amounts (< 3%) were detected in tissues all of which were in direct contact with the substance, so that it can be attributed to mechanical adherance to the tissues rather than to absorption.
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