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EC number: 948-052-1
CAS number: -
There were no deaths on the study. No signs
of systemic toxicity were noted in the test or control animals during
Body weight change of the test animals
between Day 1 and Day 6 was comparable to that observed in the
corresponding control group animals over the same period.
A study was
performed to assess the skin sensitisation potential of the test
substance in the CBA/Ca strain mouse following topical application to
the dorsal surface of the ear. The
method was designed to meet the requirements of the following guidelines:
preliminary screening test in which no clinical signs of toxicity were
noted at a concentration of 100%, this concentration was selected as the
highest dose investigated in the main test of the Local Lymph Node
Assay. Three groups, each of four animals, were treated with 50 μL (25
μL per ear) of the test item either undiluted (100% v/v), or as a
solution in acetone/olive oil 4:1 at concentrations of 50% or 25% v/v.
A further group of four animals was treated with acetone/olive oil 4:1
The Stimulation Index expressed as the mean
radioactive incorporation for each treatment group divided by the mean
radioactive incorporation of the vehicle control group are as follows:
item was considered to be a sensitiser under the conditions of the test.
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