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EC number: 812-491-6
CAS number: 1312943-23-9
There is no evidence from the experimental studies to indicate that MDI
category members are absorbed systemically. No information on
distribution, metabolism or excretion can be derived from the
data for the mammalian toxicity Annex VII and VIII endpoints have been
generated on substances within the MDI category.
following conclusions can be drawn on the basis of a review of available
key experimental data from physico-chemical and toxicological studies on
the substances performed according to international technical guidelines
and in compliance with GLP:
MDI category substances do not appear to be absorbed via the
gastrointestinal tract. This is supported by the lack of systemic
toxicity at single doses of up to 2000 mg/kg bw, as suspension via oral
gavage in the acute oral toxicity studies with Wistar rats and the
repeat oral toxicity studies with Wistar rats at concentrations up to
1000 mg/kg/bw. Alternatively, the lack of toxicity via the oral route
may also be indicative of high-threshold toxicity for the substance over
the relatively short-term exposures examined
be ruled out.
MDI substances do not appear to be absorbed via the skin. This is
supported by the lack of any systemic effects following occluded, or
semi-occluded, application of 0.5 g to rabbit skinin vivostudies.
Similarly, there was no dose dependent increases in stimulation index
following topical application of MDI substance in a local lymph node
assay. Additionally, in modified Buehler tests and guinea-pig
maximisation tests no classifiable response was observed. There is also
a lack of systematic toxicity in acute dermal toxicity studies conducted
on four MDI category members. Although lack of dermal absorption is the
likely scenario for the absence of systemic effects via this route of
exposure, the alternative explanation of high threshold toxicity over
the short-term exposure examined cannot be ruled out.
available data from these studies allows conclusions to be drawn
regarding distribution, metabolism or excretion of the polyurea MDI
substances in the marketed grease base.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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