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EC number: -
CAS number: -
The MDI category members do not show acute toxicity to aquatic organisms
at their limit of solubility. Therefore, the category members do not
meet the criteria for classification as acutely toxic to the aquatic
environment under the EU CLP regulation.
Chronic aquatic toxicity data for algae and Daphnia are available for
members of the MDI category. These data would not result in a chronic
classification under CLP as no toxicity was observed at the highest
nominal loading rate in the studies. A harmonised classification of
Aquatic Chronic 4 has been applied to the substances with EC numbers
406-690-3, 406-530-2, 406-370-3. This is a safety net classification
assigned to poorly soluble substances which are not readily
biodegradable and do not exhibit acute toxicity at the limit of
solubility. However, for the MDI category, the substance Reaction
product of 4,4'-methylenediphenyl diisocyanate and amines, coco alkyl
has been tested for toxicity to aquatic algae and in a long-term Daphnia
study. This substance was selected for testing due to it being
potentially the most water-soluble substance in the category (although
still poorly soluble) and as it contains a range of structures from C6
to C18, bracketing the structures in the category. Based on the study
results no effects were observed at highest nominal loading rate,
considered to be the limit of solubility of the test item. As chronic
data are available, and demonstrate no toxicity at the limit of
solubility, an Aquatic Chronic 4 classification is not required for
substances within the MDI category.
Additionally, high temperature stability indicates that the grease
thickener structure is robust and resistant to diffusion out of the oil.
Dissolution of grease thickeners from grease into water is very unlikely
as the thickeners are poorly water soluble and the thickeners are
embedded in the hydrophobic grease matrix and thus unlikely to leach
out, as detailed in the additional information on environmental fate
section of this dossier. The screening ecotoxicity data (using SPME-GC
and the in vitro Microtox assay), confirm a lack of toxicity of the
greases. Therefore, an aquatic chronic classification is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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