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EC number: 812-491-6
CAS number: 1312943-23-9
MDI category members do not show acute toxicity to aquatic organisms at
their limit of solubility. Therefore, the category members do not meet
the criteria for classification as acutely toxic to the aquatic
environment under the EU CLP regulation.
aquatic toxicity data for algae and Daphnia are available for members of
the MDI category. These data would not result in a chronic
classification under CLP as no toxicity was observed at the highest
nominal loading rate in the studies. A harmonised classification of
Aquatic Chronic 4 has been applied to the substances
3,3'-dioctadecyl-1,1'-methylenebis(4,1-phenylene)diurea (EC 406-690-3),
A mixture of: 3,3'-dicyclohexyl- 1,1'-methylenebis(4,1-phenylene)diurea;
3,3'-dioctadecyl-1,1'-methylenebis(4,1-phenylene)diurea (EC 406-530-2),
and 3,3'-dicyclohexyl-1,1'- methylenebis(4,1-phenylene)diurea (EC
406-370-3). This is a safety net classification assigned to poorly
soluble substances which are not readily biodegradable and do not
exhibit acute toxicity at the limit of solubility. However, for the MDI
category, the substance Reaction product of 4,4’-methylenediphenyl
diisocyanate and amines, coco alkyl has been tested for toxicity to
aquatic algae and in a long-term Daphnia study. This substance was
selected for testing due to it being potentially the most water-soluble
substance in the category (although still poorly soluble) and as it
contains a range of structures from C6 to C18, bracketing the structures
in the category. Based on the study results no effects were observed at
highest nominal loading rate, considered to be the limit of solubility
of the test item. As chronic data are available, and demonstrate no
toxicity at the limit of solubility, an Aquatic Chronic 4 classification
is not required for substances within the MDI category.
high temperature stability indicates that the grease thickener structure
is robust and resistant to diffusion out of the oil. Dissolution of
grease thickeners from grease into water is very unlikely as the
thickeners are poorly water soluble and the thickeners are embedded in
the hydrophobic grease matrix and thus unlikely to leach out, as
detailed in the additional information on environmental fate section of
this dossier. The screening ecotoxicity data (using SPME-GC and the in
vitro Microtox assay), confirm a lack of toxicity of the greases.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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