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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Acute toxicity to fish has been assessed for four substances that would fall within the MDI category definition. All studies used water accommodated fractions or saturated solutions as the test items are poorly soluble UVCBs and all determined EC50 values greater than the limit of solubility, with NOEC values equal to the limit of solubility. Based on these results, members of the MDI category are not expected to be toxic to fish at the limit of solubility.

Key value for chemical safety assessment

Additional information

Studies were performed to assess the acute toxicity of EC 406-530-2, EC 406-370-3, EC 445-760-8 and EC 406-690-3 in isolated form to fish. In all studies, the method followed was designed to be compatible with the EC Method C1 or the studies have been previously accepted for regulatory purposes. The studies were all conducted with saturated solutions of the test item.

The LC50 values determined in all of the studies were greater than the limit of water solubility for the test items. The 48-hour EC50 values for EC 406-690-3, EC 406-370-3, EC 445-760-8 and EC 406-530-2 were > 0.9 mg/L, > 1.0 mg/L, > 0.0044 mg/L and > 0.9 mg/L, respectively. The corresponding NOEC values were at the limit of solubility.