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EC number: 812-491-6
CAS number: 1312943-23-9
Acute toxicity to Daphnia magna has been assessed for four
substances that would fall within the MDI category definition. All
studies used water accommodated fractions or saturated solutions as the
test items are poorly soluble and all determined EC50 values greater
than the limit of solubility, with NOEC values equal to the limit of
solubility. Based on these results, members of the MDI category are not
expected to be toxic to aquatic invertebrates at the limit of solubility.
were performed to assess the acute toxicity of a mixture of:
3,3'-dioctadecyl- 1,1'-methylenebis(4,1-phenylene)diurea (EC 406-530-2),
3,3'-dicyclohexyl-1,1'-methylenebis (4,1-phenylene)diurea (EC
406-370-3), 3,3'-dioctadecyl-1,1'-methylenebis(4,1-phenylene)diurea (EC
406-690-3) and N,N''-(methylenedi-4,1-phenylene)bis[N'-octyl]urea (EC
445-760-8), to Daphnia magna. In all studies, the method followed was
designed to be compatible with the EC Method C2 or the studies have been
previously accepted for regulatory purposes. The studies were all
conducted with saturated solutions of the test item. Immobilisation and
any adverse reactions to exposure were recorded.
the EC50 values were greater than the limit of water solubility for the
test items. The 48-hour EC50 values for
3,3'-dioctadecyl-1,1'-methylenebis(4,1-phenylene)diurea (EC 406-690-3),
3,3'-dicyclohexyl-1,1'- methylenebis(4,1-phenylene)diurea (EC
406-370-3), N,N''-(methylenedi-4,1-phenylene)bis[N'-octyl]urea (EC
445-760-8), and A mixture of:
3,3'-dioctadecyl-1,1'-methylenebis(4,1-phenylene)diurea (EC 406-530-2),
were > 0.9 mg/L, > 1.0 mg/L, > 0.0044 mg/L and > 0.9 mg/L, respectively.
The corresponding NOEC values were at the limit of solubility.
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