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Ecotoxicological information

Toxicity to other aquatic organisms

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Reference
Endpoint:
toxicity to other aquatic vertebrates
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to
Guideline:
other: Part 18: Natural Enemy Amphibian Acute Toxicity Test of Guidance of Environmental Safety Assessment for Chemical Pesticide (draft for approval) of Ministry of Agricultural of China
Deviations:
no
GLP compliance:
no
Vehicle:
yes
Remarks:
DMF and Tween 80
Aquatic vertebrate type (other than fish):
frog
Test organisms (species):
Xenopus laevis
Test type:
semi-static
Total exposure duration:
48 h
Post exposure observation period:
3, 24 and 48 hours
Hardness:
78 to 91 mg/L
Test temperature:
23 ± 2°C
pH:
6 to 8.5
Dissolved oxygen:
> 5.8 mg/L
Nominal and measured concentrations:
100 a.i.mg/L
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality
Conclusions:
48-Hr EC50 (Frog): > 100 a.i mg/L (mortality)
Executive summary:

The study is conducted according to guideline Part 18: Natural Enemy Amphibian Acute Toxicity Test of Guidance of  Environmental Safety Assessment for Chemical Pesticide (draft for approval) of Ministry of Agricultural of China. The study was conducted to determine 48 hour acute toxicity of test substance in frog (Xenopus laevis). Treatment consists of 100 a.i. mg/L of test substance to test organism. Black control and solvent control are also present. Observations for mortality is done in all groups at 3, 24 and 48 h interval. The tadpole is recorded dead when there is no visible movement after its tail being touched by glass rod.

The results showed that there is no toxicity symptoms and mortality in both test and control group. These results conclude that LC50 value of test substance in test organism is >100 a.i.mg/L based on test solution concentration and mortality.

Description of key information

48-hour EC50 ( Xenopus laevis, frog) > 100 mg/L; Reliability = 2

Additional information