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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
gas saturation method
Key result
Test no.:
#1
Temp.:
30 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#2
Temp.:
40 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#4
Temp.:
25 °C
Vapour pressure:
0 Pa
Remarks on result:
other: Calculated
Conclusions:
Measured vapour pressure:
2.88 × 10e-8 Pa at 30°C
3.37 × 10e-8 Pa at 40°C
3.95 × 10e-8 Pa at 50°C

Extrapolated vapour pressure: 2.65 × 10e-8 Pa at 25°C
Executive summary:

This study was conducted to determine the vapour pressure of the test substance according to the regulatory guidelines OPPTS 830.7950, OECD 104 and EEC A.4 employing the gas saturation method.

The vapour pressure of the test substance was determined at three gas flow rates (approximately 20, 25, and 30 mL/min) and at three temperatures (30, 40, and 50 ± 0.5°C). The analysis of the test substance was conducted using a validated HPLC method. The mean vapour pressure values were 2.88 × 10e-8, 3.37 × 10e-8, and 3.95 × 10e-8 Pa at 30, 40, and 50°C, respectively. A vapour pressure curve was plotted using the inverse of the experimental temperature in K (1/T) on the X-axis and the log of the vapour pressure (log p) on the Y-axis. The vapour pressure of the test substance at 25°C was calculated using the slope and intercept of the regression line. The vapour pressure of test substance at 25°C was 2.65 × 10e-8 Pa (1.98 × 10e-10 mm Hg or Torr).

Description of key information

OECD Guideline 104

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information