Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 March - 01 June 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: vapour pressure balance

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Test material form:
solid: crystalline
Remarks:
crystalline powder
Details on test material:
Batch No: 11679700
Storage: at room temperature, protected from light

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
0.006 Pa
Remarks on result:
other: calculated by interpolation and extrapolation
Key result
Temp.:
25 °C
Vapour pressure:
0.008 Pa
Remarks on result:
other: calculated by interpolation and extrapolation
Key result
Temp.:
50 °C
Vapour pressure:
0.047 Pa
Remarks on result:
other: calculated by interpolation and extrapolation

Any other information on results incl. tables

The vapour pressure was determined for six temperatures in the temperature range 15 to 150 °C and in the pressure range 10-3to 1 Pa.

From the measured data points of the vapour pressure curve the constants A, B, C of the Antoine equation can be derived by regression (Microsoft Excel) of the data points.

A = 7.5949

B = -2883.27

C = 273.15.

The vapour pressure of the test item was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50°C. The measured vapour pressure values together with the measured temperatures are listed in the table in the next section "overall remarks".

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test item Adenosine-5'-monophosphate (AMP) (CAS no. 61-19-8) was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline 104 (2006). The vapour pressure of the test item was 5.8E-3 Pa at 20°C, 8.4E-3 Pa at 25°C and 4.7E-2 Pa at 50°C.
Executive summary:

The vapour pressure of the test item Adenosine-5'-monophosphate (AMP) (CAS no. 61 -19 -8) was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline 104 (2006).

The vapour pressure of the test item was 5.8E-3 Pa at 20°C, 8.4E-3 Pa at 25°C and 4.7E-2 Pa at 50°C.