Registration Dossier
Registration Dossier
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EC number: 206-596-0 | CAS number: 355-93-1
Endpoint summary
Administrative data
Description of key information
Some experimental studies have been conducted to investigate the degradation of OFPMA in the environment.
OFPMA hydrolyses rapidly in water to octafluoropentanol and methacrylic acid. The half lives of the OFPMA were reported to be 2.7 days for pH 4, 4.1 days for pH 7, and 3.9 hours for pH 9 at 25°C, using second order kinetics according to the non-GLP OECD Guideline 111 study.
OFPMA is not readily biodegradable according to two GLP-compliant OECD Guideline 310 studies. The minimum degradation reported was 22% after 28 days. Compound analysis confirmed octafluoropentanol was a biodegradation product of OFPMA. It was assumed the remaining portion of the OFPMA biodegraded to methacrylic acid which would have be further mineralized to carbon dioxide. The compound analysis did not detect further mineralization of the octafluoropentanol during the 28-day study period.
The adsorption/desorption properties of OFPMA were predicted based on the measured log Kow value. The regression method of Güsten and Sabljic (1995) has predicted the log Koc value to be 2.60 (i.e., Koc = 394). According to ECHA (2017), substances with log Koc greater than 4 are generally regarded as highly adsorptive and likely to distribute to sediment and soil. As the predicted Log Koc is less than 4, it is unlikely that OFPMA will distribute to sediment and soil.
Reference:
ECHA (2017). Guidance on Information Requirements and Chemical Safety Assessment: Chapter R.11: PBT/vPvB assessment. Version 3.0, June 2017.
Güsten H, Sabljic A (1995). QSARS for Soil Sorption. In: EC. Overview of Structure-Activity Relationships for Environmental Endpoints: Part 1: General Outline and Procedures: Report of the EU-DG-XII Project QSAR for Prediction of Fate and Effects of Chemicals in the Environment. European Commission (EC), Belgium, Chapter III, p. 6-13, 25-27. EV5V-CT92-0211 - Part 1.
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