Registration Dossier
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EC number: 206-596-0 | CAS number: 355-93-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 25, 2014 to April 28, 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Remarks:
- Each flask shaken at 30°C and given 24 hours to stabilize at room temperature before filtration
- Specific details on test material used for the study:
- Lot # 9011721157
- Key result
- Water solubility:
- 30 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 9.43
- Remarks on result:
- other: reported as 0.030 g/L; The mean value from Flask 2 and Flask 3; pH is the mean value of Flask 2 and Flask 3
- Water solubility:
- 0.03 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 9.43
- Remarks on result:
- other: The mean value from Flask 2 and Flask 3; pH is the mean value of Flask 2 and Flask 3
- Water solubility:
- 0.018 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 8.16
- Remarks on result:
- other: This result was greater 15% of the other two results and therefoe was not included in the calculation of the mean water solubility
- Water solubility:
- 0.027 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 9.37
- Remarks on result:
- other: Flask 2
- Water solubility:
- 0.032 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 9.49
- Remarks on result:
- other: Flask 3
- Details on results:
- Two of the results obtaind from the analysis were found to be within the 15% acceptable limit specified by the test standard. Hence the mean of these two concentrations was reported as the water solubillity.
- Conclusions:
- The water solubility of OFPMA was determined according to the shake flask method of EU method A.6. The study was conducted in triplicate and the results from two flasks were found to be within the 15% acceptable limit. Therefore, the mean water solubility based on two results is 0.030 g/L (equivalent to 30 mg/L) at 20°C.
Reference
Description of key information
The water solubility of OFPMA was determined according to the shake flask method of EU method A.6. The study was conducted in triplicate and the results from two flasks were found to be within the 15% acceptable limit. Therefore, the mean water solubility based on two results is 0.030 g/L (equivalent to 30 mg/L) at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 30 mg/L
- at the temperature of:
- 20 °C
Additional information
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