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EC number: 206-596-0
CAS number: 355-93-1
The acute oral toxicity of the substance was investigated
following a GLP compliant OECD Guideline 425 study. In total, five
female non-pregnant and nulliparous Wistar albino rats were dosed with
2000 mg/kg bw of OFPMA according to up-and-down procedure. The rats were
observed at 0.5, 1, 2, and 4 hours post dose and once daily for 14 days
for toxicity and pharmacological effects. All animals were observed
twice daily for mortality. Body weights were recorded immediately
pretest, weekly and at termination. All animals were examined for gross
All animals survived the 2000 mg/kg bw oral dose with transient
clinical signs observed during the day of dosing. Instances of wetness
of the anogenital area, ataxia, prostration, flaccid muscle tone and
coma were noted on the day of dosing. The symptoms occurred quickly
after dosing and were transient in nature. All animals appeared normal
from day 1 through day 14. Body weight changes were normal in 4/5
animals. One animal lost weight during the second week of the
observation period. Necropsy results were normal.
The acute oral LD50 of the substance is greater than 2000 mg/kg bw.
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