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EC number: 269-950-3
CAS number: 68391-42-4
Study conducted according to OECD
guideline 405. Three female New Zealand White rabbits were exposed to
test substance for 24 h. After gently pulling the lower lid away from
the eye, a volume of 100 µl of pulverized test substance (equivalent to
approximately 68 mg) was placed into the conjunctival sac of one eye of
each rabbit. The lids were then gently held together for about one
second in order to limit loss of the material. 24 h after instillation
of the test substance, the treated eye was rinsed with normal saline.
Eye irritation (Draize scoring): signs of
cornea (opacity, and area affected), iris (hyperaemia, reaction to
light), conjunctivae i.e. conjunctiva of bulbus, lids, and nictitating
membrane (erythema, chemosis), and discharge were recorded after 1, 24,
48, 72 h and 7 d. In parallel, the opacity of the aqueous humour
(McDonald and Shadduck method) was also assessed for potential
Effects on conjunctivae in terms of
chemosis and redness were noted in rabbits. However, slight reactions of
the mucous membranes were fully reversible within 7 d. Test substance
was not irritant to rabbit eye.
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