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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute oral toxicity for CAS No.: 55-55-0
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplusA TOXNET Database, 2017
Reference Type:
secondary source
Title:
Initial Submission: Letter from Eastman Kodak Co to USEPA Regarding Toxicity Studies of 4-(methylamino)phenol Sulfate with Attachments and Cover Letter dated 082892.
Author:
NTRL
Year:
1992
Bibliographic source:
OTS0570966, NTRL, dated 082892

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of 4-Methylaminophenol sulphate was performed in mouse.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material: p-Methylaminophenol sulfate
- IUPAC name: Bis(4-hydroxy-N-methylanilinium) sulphate
- Molecular formula: C14H20N2O6S
- Molecular weight: 344.386 g/mole
- Smiles:CNc1ccc(cc1)O.CNc1ccc(cc1)O.OS(=O)(=O)O
- Inchl: 1S/2C7H9NO.H2O4S/c2*1-8-6-2-4-7(9)5-3-6;1-5(2,3)4/h2*2-5,8-9H,1H3;(H2,1,2,3,4)
- Substance type: Organic
- Physical state: Solid crystalline (off white - white)
Specific details on test material used for the study:
- Name of test material: p-Methylaminophenol sulfate- IUPAC name: Bis(4-hydroxy-N-methylanilinium) sulphate- Molecular formula: C14H20N2O6S- Molecular weight: 344.386 g/mole- Smiles:CNc1ccc(cc1)O.CNc1ccc(cc1)O.OS(=O)(=O)O- Inchl: 1S/2C7H9NO.H2O4S/c2*1-8-6-2-4-7(9)5-3-6;1-5(2,3)4/h2*2-5,8-9H,1H3;(H2,1,2,3,4)- Substance type: Organic- Physical state: Solid crystalline (off white - white)

Test animals

Species:
mouse
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: 0.5% Jaguar(guar-gum)
Details on oral exposure:
Details on exposureVEHICLE- Concentration in vehicle:565 mg/kg bw- Amount of vehicle (if gavage): No data available- Justification for choice of vehicle: Test material soluble in vehicle - Lot/batch no. (if required): No data available- Purity: No data availableMAXIMUM DOSE VOLUME APPLIED: No data availableDOSAGE PREPARATION (if unusual): 10% suspension of the compound in 0.5% Jaguar(guar-gum)CLASS METHOD (if applicable)- Rationale for the selection of the starting dose No data available
Doses:
565mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
565 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed
Clinical signs:
Behavioral changes like somnolence (general depressed activity) and tremor were observed
Body weight:
No data available
Gross pathology:
No data available
Other findings:
Effect on kidney, ureter, and bladder and changes in urine composition were noted.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be 565mg/kg bw. When mouse were treated with 4-Methylaminophenol sulphate (55-55-0) orally.
Executive summary:

In acute oral toxicity study, mice were treated with4-Methylaminophenol sulphate (55-55-0)orally. The dose concentration was prepared in10% suspension of the compound in 0.5% Jaguar (guar-gum).50% mortality was observed in treated mouse at 565 mg/kg bw. Behavioral changes like somnolence (general depressed activity) and tremor were observed also effect on kidney, ureter, and bladder and changes in urine composition were noted in treated mice. Therefore, LD50 was considered to be 565mg/kg bw. When mouse were treated with4-Methylaminophenol sulphate(55-55-0) orally.