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Density

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Reference
Endpoint:
density, other
Remarks:
Density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07-10-2017 – 07-10-2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard OECD test guidelines
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
The density of Test item Bis(4-hydroxy-N-methylanilinium) sulphate (CAS No. 55-55-0) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.
GLP compliance:
not specified
Type of method:
pycnometer method
Test material information:
Composition 1
Specific details on test material used for the study:
- Name of test material: p-Methylaminophenol sulfate
- IUPAC name: Bis(4-hydroxy-N-methylanilinium) sulphate
- Molecular formula: C14H20N2O6S
- Molecular weight: 344.386 g/mole
- Smiles:CNc1ccc(cc1)O.CNc1ccc(cc1)O.OS(=O)(=O)O
- Inchl: 1S/2C7H9NO.H2O4S/c2*1-8-6-2-4-7(9)5-3-6;1-5(2,3)4/h2*2-5,8-9H,1H3;(H2,1,2,3,4)
- Substance type: Organic
- Physical state: Solid crystalline (off white - white)
Key result
Type:
pour density
Density:
0.598 g/cm³
Temp.:
20 °C
Remarks on result:
other: (970.0 hPa pressure)
Key result
Type:
tap density
Density:
0.69 g/cm³
Temp.:
20 °C
Remarks on result:
other: (970.0 hPa pressure)

TEST ITEM DESCRIPTION AND RESULTS

 

FOR SOLIDS:

By Pour Density and Tapped Density Method:

 

Method Details

Observations

Remarks if,

any

Guideline

OECD 109

1st

Reading

2ndReading

 

 

 

Method

Test methods: Pour density

and tapped density of powders” recommended inThe International Pharmacopoeia, Fourth Edition, 2014

 

 

Principle of method

Pour Density: It is the ratio of known weight of test item and its volume in graduated glass cylinder.

Tap Density:It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.

 

 

Test temperature (°C)

-

26°C

27°C

Atmospheric

pressure (in hPa)

-

971.0

969.0

Weight of test

item(m)

 

20.007

20.009

Volume of measuring

cylinder; readability in g

 

50 ml;1 ml

50 ml;1 ml

Volume of test item

without tapping (V)

 

32

35

Volume of test item

after tapping ( V1)

After 10 tapping

31

32

 

After 50 tapping

30

30

 

After 100 tapping

29

29

 

After 250 tapping

28

29

 

After 500 tapping

28

29

 

After 750 Tapping

-

-

*ρat=density of air at 27°C and 760 mm Hg pressure=0.001168 g/cm³

**Density of water referred from the Table 1 of the was method.

CALCULATIONS:

 

FOR SOLIDS:

By Pour Density and Tapped Density Method:

 

Parameters

 

Details

Calculated values

Average Density

1st Calculation

2nd Calculation

Pour Density of test Item (g/cm³)

=mV

0.6252

0.5716

0.5984

Tap density of test Item (g/cm³)

=mV1

0.6898

0.6899

0.6899

Conclusions:
The mean pour density and tapped density of Bis(4-hydroxy-N-methylanilinium) sulphate (CAS No. 55-55-0) was found to be 0.5984 g/cm³ and 0.6899 g/cm³ at 20°C and 970.0 hPa. .
Executive summary:

The density of test item Bis(4-hydroxy-N-methylanilinium) sulphate (CAS No. 55-55-0) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth

Edition, 2014 using bulk density apparatus The mean pour density and tapped density of test item was found to be 0.5984 g/cm³ and 0.6899 g/cm³ at 20°C and 970.0 hPa.

Description of key information

The mean pour density and tapped density of Bis(4-hydroxy-N-methylanilinium) sulphate (CAS No. 55-55-0) was found to be 0.5984 g/cm³ and 0.6899 g/cm³ at 20°C and 970.0 hPa. .

Key value for chemical safety assessment

Relative density at 20C:
0.69

Additional information

The density of test item Bis(4-hydroxy-N-methylanilinium) sulphate (CAS No. 55-55-0) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth

Edition, 2014 using bulk density apparatus The mean pour density and tapped density of test item was found to be 0.5984 g/cm³ and 0.6899 g/cm³ at 20°C and 970.0 hPa.