Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Hydrolysis:

Half life of hydrolysis of test chemical Bis(4-hydroxy-N-methylanilinium) sulphate (CAS no. 55-55-0) is predicted using OECD QSAR tool box v3.3 using log Kow as primary descriptor. The half life of hydrolysis of test chemical Bis(4-hydroxy-N-methylanilinium) sulphate was estimated to be 153.80 days. Since half hife of hydrolysis for this chemical is more than 10 days this chemical is considered to be non hydrolysable.

Additional information

Hydrolysis:

Predicted data for target compound Bis(4-hydroxy-N-methylanilinium) sulphate (CAS no. 55-55-0) and supporting weight of evidence study for its closest read across chemical with log Kow as primary descriptor were reviewed for the Hydrolysis endpoint which is summarized below.

Half life of hydrolysis of test chemical Bis(4-hydroxy-N-methylanilinium) sulphate (CAS no. 55-55-0) is predicted using OECD QSAR tool box v3.3 using log Kow as primary descriptor. The half life of hydrolysis of test chemical Bis(4-hydroxy-N-methylanilinium) sulphate was estimated to be 153.80 days. Since half hife of hydrolysis for this chemical is more than 10 days this chemical is considered to be non hydrolysable.

Similarly, in supporting weight of evidence study done from Hazardous Substance Data Bank,( HSDB, 2017) the half life of hydrolysis of read across chemical (2-hydroxy-4-(octyloxy)phenyl)(phenyl)methanone (CAS no. 1843-05-6) was determined by using OECD guideline 111. The half life of hydrolysis of read across chemical (2-hydroxy-4-(octyloxy)phenyl)(phenyl)methanone at pH 4, 7 and 9 determined was greater than 1 year and at 50 oC temperature . Since half life of hydrolysis at pH 4, 7 and 9 is greater than 10 days so it is concluded that read across chemical (2-hydroxy-4-(octyloxy)phenyl)(phenyl)methanone is not expected to undergo hydrolysis.

On the basis of results for target chemical Bis(4-hydroxy-N-methylanilinium) sulphate (CAS no. 55-55-0) (From OECD QSAR tool box v3.3) and for its read across chemicals (from HSDB, 2017) it is concluded that target chemical Bis(4-hydroxy-N-methylanilinium) sulphate is not expected to undergo hydrolysis.