Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- other: epidemiology
- Adequacy of study:
- supporting study
- Rationale for reliability incl. deficiencies:
- other: Only abstract available (study in Chinese)
Data source
Reference
- Reference Type:
- publication
- Title:
- Chronic toxic effect of chloroethanol
- Author:
- Yu X, Li Y, Wang Y, Lui J, Li M
- Year:
- 1 997
- Bibliographic source:
- Gongye Weisheng Yu Zhiyebing 23(1): 31-32
Materials and methods
- Study type:
- cohort study (retrospective)
- Endpoint addressed:
- repeated dose toxicity: inhalation
- Principles of method if other than guideline:
- Toxic effects in workers exposed during working shift to the test substance for more than 2 years
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chloroethanol
- EC Number:
- 203-459-7
- EC Name:
- 2-chloroethanol
- Cas Number:
- 107-07-3
- Molecular formula:
- C2H5ClO
- IUPAC Name:
- 2-chloroethan-1-ol
- Details on test material:
- no details
Constituent 1
Method
- Details on study design:
- Contact level and chronic toxic effects in 61 workers in a chloroethanol workshop studied; 60 workers without toxic substance contact history served as controls .
- Exposure assessment:
- measured
Results and discussion
- Results:
- In analytical workers the incidence of neurothenia and anorexia were significantly increased; blood cholesterol level was significantly higher (comment: comparison to normal range questionable).
Two cases of salivary antipyrine clearance below 30 ml/min., indicating possible mixed function oxidase inhibition; RUN, glutathione content, LDH isoenzyme, transpeptidase, urinary beta .2-microglobulin, blood and urine routine, liver function test, EGG and EEG were normal.
No further data - Confounding factors:
- no data
- Strengths and weaknesses:
- not assignable
Any other information on results incl. tables
Small cohort size
Applicant's summary and conclusion
- Conclusions:
- In a chinese cohort study on workers exposed to an average of 4 mg/m³ per shift for more than 2 years a significant increase in the incidence of neurothenia and anorexia was found, however, the study was hampered by small cohort size.
- Executive summary:
Chronic toxic effects in 61 chinese workers in a chloroethanol workshop were studied and compared with 60 workers without toxic substance contact history (only abstract available, no details). The average exposure level was 4 mg/m³ and the average exposure duration 11 years. The incidence of neurothenia and anorexia were significantly increased; blood cholesterol level was significantly higher.
Conclusion: In a chinese cohort study on workers exposed to an average of 4 mg/m³ per shift for more than 2 years a significant increase in the incidence of neurothenia and anorexia was found, however, the study was hampered by small cohort size.
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