Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-459-7
CAS no.:
107-07-3
Index number:
Molecular formula:
C2H5ClO
SMILES:
OCCCl
InChI:
InChI=1S/C2H5ClO/c3-1-2-4/h4H,1-2H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
6
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if swallowed, is fatal in contact with skin and is fatal if inhaled.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is toxic to aquatic life with long lasting effects, is a flammable liquid and vapour, causes serious eye damage and may be corrosive to metals.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may be fatal if swallowed and enters airways, may cause genetic defects, may cause cancer, causes damage to organs through prolonged or repeated exposure, is a highly flammable liquid and vapour and causes skin irritation.

Breakdown of all 177 C&L notifications submitted to ECHA

Acute Tox. 2 H300 Harmonised Classification
Acute Tox. 1 H310 Harmonised Classification
Flam. Liq. 3 H226
Eye Dam. 1 H318
Met. Corr. 1 H290
Acute Tox. 2 H330 Harmonised Classification
Acute Tox. 1 H330
Aquatic Chronic 2 H411
Aquatic Chronic 3 H412
Asp. Tox. 1 H304
Muta. 1B H340
Carc. 1A H350
STOT RE 1 H372
Flam. Liq. 2 H225
Eye Irrit. 2 H319
https://echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 6 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 - 10 tonnes per year.

This substance is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: laboratory chemicals.

This substance is used in the following areas: scientific research and development.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers and laboratory work.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

This substance is used in the following products: laboratory chemicals and textile treatment products and dyes.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: laboratory chemicals and pharmaceuticals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: scientific research and development. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use only outdoors or in a well-ventilated area; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; wear respiratory protection.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. Rinse the mouth. If on skin: gently wash with soap and water. Remove/take off immediately all contaminated clothing.

Storage statements

Store this substance in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Aceto France, 43 avenue marceau 75116 Paris France
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • CBW Chemie GmbH Bitterfeld-Wolfen, Kühlturmstrasse 06803 Bitterfeld-Wolfen / OT Greppin Germany
  • FORTISCHEM a.s., M.R.Stefanika 1 972 71 Novaky Slovakia
  • Honeywell Specialty Chemicals Seelze GmbH, Wunstorfer Strasse 40 D-30926 Seelze Lower Saxony Germany
  • Pulcra Chemicals GmbH, Isardamm 79-83 82538 Geretsried Germany
  • DBH Osthandelsgesellschaft mbH, Storkower Straße 139 b 10407 Berlin Germany

Substance names and other identifiers

2-chloroethanol
EC Inventory, C&L Inventory, REACH pre-registration
ethylene chlorohydrin
C&L Inventory
2-chloorethanol (nl)
C&L Inventory
2-Chlor-ethanol (de)
C&L Inventory
2-chloretanolis (lt)
C&L Inventory
2-chlorethan-1-ol (cs)
C&L Inventory
2-chlorethanol (da)
C&L Inventory
2-chloroetanol (pl)
C&L Inventory
2-chloroéthanol (fr)
C&L Inventory
2-chlóretanol (sk)
C&L Inventory
2-clor etanol (ro)
C&L Inventory
2-cloroetanol (es)
C&L Inventory
2-cloroetanolo (it)
C&L Inventory
2-hloretanols (lv)
C&L Inventory
2-kloretanol (no)
C&L Inventory
2-kloroetanol (hr)
C&L Inventory
2-kloroetanool (et)
C&L Inventory
2-klóretanol (hu)
C&L Inventory
2-χλωροαιθανόλη (el)
C&L Inventory
2-хлороетанол (bg)
C&L Inventory
alkohol 2-chloroetylowy (pl)
C&L Inventory
bis(2-clor etil) eter (ro)
C&L Inventory
chlorohydryna etylenu (pl)
C&L Inventory
cloridrina etilenica (it)
C&L Inventory
ethyleen-chloorhydrine (nl)
C&L Inventory
ethylenchlorhydrin (cs)
C&L Inventory
etilen klorohidrin (sl)
C&L Inventory
etilen-clorhidrina (es)
C&L Inventory
etilen-klorohidrin (hr)
C&L Inventory
etilenchlorhidrinas (lt)
C&L Inventory
etilenocloridrina (pt)
C&L Inventory
etilén-klórhidrin (hu)
C&L Inventory
etilēnhlorhidrīns (lv)
C&L Inventory
Etyleenikloorihydriini (fi)
C&L Inventory
etylenklorhydrin (no)
C&L Inventory
Etylenochlorohydryna (pl)
C&L Inventory
etylén-chlórhydrín (sk)
C&L Inventory
etüleenklorohüdriin (et)
C&L Inventory
glycolmonochloorhydrine (nl)
C&L Inventory
éthylène-chlorhydrine (fr)
C&L Inventory
αιθυλενο-χλωροϋδρίν (el)
C&L Inventory
етилен хлорохидрин (bg)
C&L Inventory
Ethanol, 2-chloro-
Other
1-Chloro-2-hydroxyethane
C&L Inventory
2-chloroethan-1-ol
Other
2-chloroethanol;
C&L Inventory
ethylene chlorhydrin
Registration dossier
.beta.-Chloroethanol
Registration dossier
.beta.-Chloroethyl alcohol
Registration dossier
.beta.-Hydroxyethyl chloride
Registration dossier
2-Chloro-1-ethanol
Registration dossier
2-Chloroethyl alcohol
Registration dossier
2-Hydroxyethyl chloride
Registration dossier
Chloroethanol
Registration dossier
ECH
Registration dossier
Ethene chlorohydrin
Registration dossier
Ethylchlorohydrin
Registration dossier
Ethylene chlorohydrine
Registration dossier
Glycol chlorohydrin
Registration dossier
Glycol monochlorohydrin
Registration dossier
107-07-3
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other
1253945-55-9
Deleted CAS number
Other
1867-09-0
Deleted CAS number
Other
603-028-00-7
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 5 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [4]
C Form
Viscous (50%), Other (50%) [2]
C Odour
Other (100%) [4]
C Substance type
Organic (75%), Inorganic (25%) [4]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 3
Other 1
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 9 studies submitted
  • 4 studies processed
R Melting / freezing point
-70 - -62.6 °C @ 101.3 kPa [4]

Type of Study provided
Studies with data
Key study
Supporting study 1 3
Weight of evidence 4
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-67.5 °C

Boiling point

Study results
  • 11 studies submitted
  • 4 studies processed
R Boiling point
128 - 130 °C @ 101.3 - 101.325 kPa [4]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 7 2
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Boiling point at 101 325 Pa
128 °C

Density

Study results
  • 10 studies submitted
  • 4 studies processed
R Density
1.21 - 1.213 g/cm³ @ 20 °C [2]
R Relative density
1.197 - 1.202 @ 20 °C [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6 1
Other 3
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.197 - 1.2

Vapour pressure

Study results
  • 9 studies submitted
  • 5 studies processed
R Vapour pressure
6.5 - 990.97 hPa @ 17.5 - 127.5 °C [9]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence 4
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
8.4 - 712 Pa @ 20 °C

Partition coefficient

Study results
  • 7 studies submitted
  • 5 studies processed
R Log Pow
-0.06 - 1.06 @ 25 °C [5]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence 2 2
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
-0.06 - 1.06 @ 20 °C

Water solubility

Study results
  • 7 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
1 000 g/L @ 20 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 3 3
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Water solubility
1 000 g/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 12 studies submitted
  • 5 studies processed
R Flash point
40.56 - 60 °C [5]

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence 5 3
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
40.56 °C

Auto flammability

Study results
  • 7 studies submitted
  • 5 studies processed
R Autoflammability / self-ignition
379 - 425 °C [5]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 4
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 6
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 17 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 14
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 5.6 µg/L (1)
Intermittent releases (freshwater) 56 µg/L (1)
Marine water 560 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 20 mg/L (1)
Sediment (freshwater) 21.2 µg/kg sediment dw (1)
Sediment (marine water) 2.12 µg/kg sediment dw (1)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 683 ng/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 16 studies submitted
  • 2 studies processed
P/RResults
LC50 (3.2 months) 21.6 - 28.5 mg/L [2]
LC50 (4 days) 15.2 - 54.6 mg/L [9]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 14
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 23 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 212 mg/L [1]
LC50 (48 h) 118 - 235 mg/L [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 20
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Data not provided by the registrant

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 2.85 - 5.6 mg/L [3]
EC10 (72 h) 290 - 950 µg/L [3]
EC90 (72 h) 28.06 - 30.52 mg/L [3]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 7
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (72 h) 62.3 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Data not provided by the registrant

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 5 3
Weight of evidence
Other 1 6
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 22 studies submitted
  • 1 study processed
P/RResults
LD50 77 mg/kg bw (rat) [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 11 4
Weight of evidence
Other 5
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
inhalation
  • 15 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other 8
Data waiving
no waivers
dermal
  • 18 studies submitted
  • 4 studies processed
P/RResults
LD50 330 - 470 mg/kg bw (rat) [2]
LD50 1 300 - 1 940 mg/kg bw (mouse) [2]
LD50 260 mg/kg bw (guinea pig) [1]
LD100 320 mg/kg bw (guinea pig) [1]
LD50 68 mg/kg bw (rabbit) [1]

dermal
Studies with data
Key study 4
Supporting study 4
Weight of evidence
Other 1 9
Data waiving
no waivers
other routes
  • 36 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 12 1
Weight of evidence
Other 23
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence 3
Other 8 4
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: eye
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study 8
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 11 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 3 5
Data waiving
no waivers
Study data: inhalation
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study 1 1
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 4 5
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Genetic toxicity

Study results
Study data: in vitro
  • 101 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 9
Supporting study 41 1
Weight of evidence
Other 50
Data waiving
no waivers
Study data: in vivo
  • 35 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 4
Supporting study 11
Weight of evidence
Other 20
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other 7
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Study data: developmental
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other 7
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant