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EC number: 203-459-7
CAS number: 107-07-3
in the 1st trial 4/12 rats died at 12.8 mg/kg bw; authors presumed an
overdose and repeated the experiment; no mortality was found at this
dose level. At 32 mg/kg bw 6/12 rats died. No mortality occurred at 6.4
Body weight gain, food consumption, hematology, pathology: no
significant treatment related effects.
The study meets scientific standards with acceptable restrictions
(partly limited documentation).
In a subchronic study 12 -24 male Sprague-Dawley rats per group received
thrice weekly i.p. injections of 0, 6.4, 12.8, 32 mg/kg bw/injection for
12 weeks. Clinical signs, food consumption, body weight, hematology,
necropsy data, organ weights were recorded and histopathology of
selected organs performed. Survival was reduced at 32 mg/kg bw. No
further treatment related effects were detected.
Conclusion: No adverse effects were detected in male rats after thrice
weekly i.p. injection for 12 weeks at a dose level of 12.8 mg/kg
bw/injection, the LOAEL was 32 mg/kg bw/injection.
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