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EC number: 203-459-7
CAS number: 107-07-3
The study meets scientific standards with acceptable restrictions (e.g.
partly limited documentation, e.g. no details about the test substance).
In trial 1 4 male B6C3F1 mice were i.p. injected once with 24, 48, or
72.5 mg/kg bw (untreated control) and liver glutathione levels measured
1.5 and 3 h after application. A depletion to 30% of untreated control
level at the high dose level 1.5 h after injection was measured and a
slight amelioration was found after 3 h. Similar but less severe effects
were found at lower doses.
In the 2nd trial 3 -6 male B6C3F1 mice per groupp received single i.p.
injections of 0, 24, 48, 72.5, or 97 mg/kg bw and sacrificed 24 h later.
Liver weight was significantly increased at the high dose level as well
as serum iditol dehydrogenase and serum alanine aminotransferase.
Conclusion: Toxic dose levels resulted in depletion of liver glutathione
and in liver toxicity in mice.
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