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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data is from Authoritive data base

Data source

Reference
Reference Type:
other: authorative data base
Title:
Skin sensitization CAS No: 121­57­3 (Sulfanilic acid)
Author:
IFA (GESTIS)
Year:
2016
Bibliographic source:
GESTIS Substance Database (Information System in Hazardous Substance of the Berufsgenossenscheftn)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The skin sanitization test of Benzyl cyanide was conducted in guinea pigs to determine sensitization potential of Sulfanilic acid
GLP compliance:
not specified
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
Not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Test material form:
other: solid
Details on test material:
- Name of test material (as cited in study report): 4­Aminobenzenesulfonic acid- Molecular formula: C6H7NO3S- Molecular weight: 173.19 g/mol- Substance type: Organic- Physical state: solid-Smiles:S(c1ccc(N)cc1)(O)(=O)=O-InChI:1S/C6H7NO3S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H,8,9,10)

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: No data available
Vehicle:
no data
Concentration / amount:
No data available
Challengeopen allclose all
Route:
other: No data available
Vehicle:
no data
Concentration / amount:
No data available
No. of animals per dose:
No data available
Details on study design:
No data available
Challenge controls:
No data available
Positive control substance(s):
not specified

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test group
Dose level:
No data available
Clinical observations:
Potential skin sensitizer
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: No data available. Clinical observations: Potential skin sensitizer.

Any other information on results incl. tables

not specified

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test material Sulfanilic acid (CAS No: 121­57­3) was observed to be sensitizing on guinea pigs.
Executive summary:

The skin sensitization reaction was carried out in guinea pigs by guinea pig maximization test for test chemical Sulfanilic acid (CAS No: 121­57­3).

 

Since skin effects were observed the test chemical Sulfanilic acid (CAS No: 121­57­3) was considered to be sensitizing to guinea pigs.