Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-846-5 | CAS number: 88-63-1
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound 2,4-Diaminobenzene sulfonic acid (CAS no. 88-63-1) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that 2,4-Diaminobenzenesulfonic acid is not expected to be readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The predicted data for the test compound 2,4-Diaminobenzenesulfonic acid (CAS No. 88-63-1) and the study for its read across substance were reviewed for the biodegradation end point which are summarized as below:
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound 2,4-Diaminobenzene sulfonic acid (CAS no. 88-63-1) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that 2,4-Diaminobenzenesulfonic acid is not expected to be readily biodegradable.
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance Sulfanilic acid (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 100 mg/l and initial test substance conc. used in the study was 30 mg/l. The percentage degradation of test substance was found to be 3% by BOD, 4% by TOC removal and 1% by HPLC in 28 days. Thus, the substance Sulfanilic acid is not expected to be readily biodegradable in water.
Biodegradation study was conducted according to MITI Test for 14 days for evaluating the percentage biodegradability of read across substance Sulfanilic acid (HSDB, 2016). Conc. of inoculum used for the study was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 8% by ThBOD in 14 days Thus, the substance Sulfanilic acid was evaluated to be not readily biodegradable in water.
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance Sulfanilic acid (GSBL database, 2016). Initial test substance conc. used in the study was 2 mg/l. The percentage degradation of test substance was found to be 55% by using BOD and COD parameter in 28 days. Thus, the substance Sulfanilic acid is not expected to be readily biodegradable in water.
Biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of read across substance 2-Amino-5-chloro-4 -methylbenzene sulfonic acid (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was found to be 0% by O2 consumption & BOD, 2% by TOC removal and < 0% by Test mat. analysis & UV-Vis in 14 days. Thus, the substance 2-Amino-5-chloro-4-methylbenzenesulfonic acid is not expected to be readily biodegradable in water.
Biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of read across substance 2-Amino-5-methylbenzenesulfonic acid(J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was found to be 0% by O2 consumption & BOD and < 0 % by TOC removal, Test mat. analysis & UV-Vis in 14 days. Thus, the substance 2-Amino-5-methylbenzenesulfonic acid is not expected to be readily biodegradable in water.
On the basis of above results for target and read across substances, it can be concluded that the test substance compound 2,4 -Diaminobenzenesulfonic acid can be expected to be not readily biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
