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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from authorative handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
Acute oral toxicity study of 1,3-Phenylenediamine-4-sulfonic acid in rat
Author:
Richard J Lewis
Year:
2012
Bibliographic source:
Sax’s Dangerous Properties of Industrial Materials, 12th Edition

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: refer below principle
Principles of method if other than guideline:
Acute oral toxicity study of 1,3-Phenylenediamine-4-sulfonic acid in rat.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material: 2,4-Diaminobenzenesulfonic acid- Molecular formula: C6H8N2O3S- Molecular weight : 188.206 g/mol- Smiles notation: O=S(=O)(O)c1c(N)cc(N)cc1- InChl : 1S/C6H8N2O3S/c7-4-1-2-6(5(8)3-4)12(9,10)11/h1-3H,7-8H2,(H,9,10,11)- Substance type: Organic- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
3480 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 480 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
No data available
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
Acute oral LD50 value of 1,3-Phenylenediamine-4-sulfonic acid is considered to be 3480 mg/kg in rat.
Executive summary:

Acute oral toxicity test of 1,3-Phenylenediamine-4-sulfonic acid was conducted with rat in the concentration of 3480 mg/kg mg/kg bw orally. 50 % mortality was observed in treated rat. Therefore, LD50 was considered to be 3480 mg/kg when rats were treated with 2,4-diaminobenzenesulphonic acid orally.