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EC number: 203-214-4
CAS number: 104-57-4
A test was conducted to assess the eye
irritating potential ot the test item to rabbits' eyes. Four SPF albino
rabbit were used. The study was performed in accordance to GLP and OECD
Guideline 405. After a single application of 0.1 mL of the test item,
the animals were observed for a period of 7 days and eye reactions were
recorded at 1, 24, 48 and 72 hours. The mean scores for cornea opacity
calculated for the time points 24, 48 and 72 hours were 0, 0, 0.7 and
0.3 for animal 1, 2, 3 and 4, respectively. Iris mean scores were 0 for
each of the four animals. The conjunctiva scores were calculated to be
0.7, 0.7, 1.7, 1.7 and chemosis scores were 0, 0.3, 0.7, 0.3. All
findings were reversible within the observation period of 7 days. On the
basis of four results, the substance is considered to be non irritating
to the rabbits' eyes.
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