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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-02-02
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
2004
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
Noack Laboratorien GmbH, Käthe-Paulus-Str. 1, 31157 Sarstedt, Germany.
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Test material information:
Composition 1
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.79
Temp.:
21.9 °C
Remarks on result:
other: Mean value of 2 measurements; no pH value was reported but the mobile phase is neutral.

Table. 1: Summarozed Results of the Partition Coefficient

Log Pow

1stCalibration

2ndCalibration

Mean

1.79±0.03

1.72 to 1.87 (95% CI)

1.79±0.03

1.72 to 1.87 (95% CI)

1.79

Pow: Partition Coefficient (n-octanol/water)

CI: Conficence interval

Conclusions:
The partition coefficient of the test substance was determined to be 1.79 at 21.9 °C.
Executive summary:

The partition coefficient of the test substance was determined according to OECD Guideline 117 and EU Method A.8 by the HPLC method. The test was performed with a concentration of 10 mg/L of the test item in 35% acetonitrile : 65 % HPLC water. Samples of the test item were analysed via HPLC on a C18 column with diode array detection. Calibration was performed using seven reference items with known log Pow values. A mean log Pow value of 1.79 at 21.9 °C was determined for the test substance.

Description of key information

Partition coefficient of the test item was determined to be log Pow = 1.79 at 21.9 °C.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.79
at the temperature of:
21.9 °C

Additional information

The octanol-water partition coefficient of the substance was determined according to OECD 117 by the HPLC method. A log Pow value of 1.79 at 21.9 °C was determined for the test substance and is considered as reliable.